Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1716060..1717199 Replicon chromosome
Accession NZ_CP045118
Organism Pseudomonas sp. SCB32

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GA645_RS08150 Protein ID WP_152227976.1
Coordinates 1716453..1717199 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GA645_RS08145 Protein ID WP_152221642.1
Coordinates 1716060..1716428 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GA645_RS08110 1711120..1711503 - 384 WP_152221629.1 VOC family protein -
GA645_RS08115 1711909..1712715 - 807 WP_152221631.1 phytanoyl-CoA dioxygenase family protein -
GA645_RS08120 1712813..1713706 + 894 WP_152221633.1 LysR family transcriptional regulator -
GA645_RS08125 1713897..1714265 + 369 WP_152221635.1 hypothetical protein -
GA645_RS08130 1714469..1714852 - 384 WP_152221637.1 hypothetical protein -
GA645_RS08135 1714957..1715301 - 345 WP_152221638.1 carboxymuconolactone decarboxylase family protein -
GA645_RS08140 1715433..1715915 - 483 WP_152221640.1 transcription elongation factor GreAB -
GA645_RS08145 1716060..1716428 + 369 WP_152221642.1 DUF2384 domain-containing protein Antitoxin
GA645_RS08150 1716453..1717199 + 747 WP_152227976.1 RES family NAD+ phosphorylase Toxin
GA645_RS08155 1717276..1717485 + 210 WP_152221644.1 hypothetical protein -
GA645_RS08160 1718075..1719439 + 1365 WP_178119619.1 DNA recombination protein RmuC -
GA645_RS08165 1719482..1720828 - 1347 WP_152221648.1 FAD-binding oxidoreductase -
GA645_RS08170 1720917..1721807 - 891 WP_152221651.1 metal-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(59-204)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-50)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 28107.20 Da        Isoelectric Point: 8.9154

>T141244 WP_152227976.1 NZ_CP045118:1716453-1717199 [Pseudomonas sp. SCB32]
IWATHEPESVVTSIRGRLVRLVESQGQVATLQLVDTLAEQALLEELLETSKPRVPPPAAHLHYLLKTPFRYPPLRWGSRF
GRRHEPSLFYAALKLDTAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQRGVRLQLPPFREYEPALRDPSDYR
VAQGLGSAMREAGVEAFEYRSARCPHGGVNVALFAPSAFTEKRPRNLMPWLCETTAEYVAFKHAQVPDTPRLFPRTQFLV
DGHLPYPA

Download         Length: 747 bp

>T141244 NZ_CP059907:c536310-535999 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13437.69 Da        Isoelectric Point: 9.7742

>AT141244 WP_152221642.1 NZ_CP045118:1716060-1716428 [Pseudomonas sp. SCB32]
MSALLRESPAADAVLAKAVLTAREHLAMTQQELATIVGVERSAVSRWKQGGLRVDSKTGELALLLVRVYRALFALFGGNL
EDMRHFLRTENRHLSGVPLQLMEQVQGLVAVVEYLDAIRGKV

Download         Length: 369 bp

>AT141244 NZ_CP059907:c535998-535708 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References