Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1571803..1572437 Replicon chromosome
Accession NZ_CP045118
Organism Pseudomonas sp. SCB32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GA645_RS07350 Protein ID WP_152221355.1
Coordinates 1571803..1572207 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GA645_RS07355 Protein ID WP_152221357.1
Coordinates 1572207..1572437 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GA645_RS07330 1567822..1568898 - 1077 WP_152221347.1 phosphotransferase -
GA645_RS07335 1568994..1570025 - 1032 WP_152221349.1 ABC transporter substrate-binding protein -
GA645_RS07340 1570290..1571024 + 735 WP_152221351.1 SDR family oxidoreductase -
GA645_RS07345 1571112..1571786 + 675 WP_152221353.1 GntR family transcriptional regulator -
GA645_RS07350 1571803..1572207 - 405 WP_152221355.1 tRNA(fMet)-specific endonuclease VapC Toxin
GA645_RS07355 1572207..1572437 - 231 WP_152221357.1 antitoxin Antitoxin
GA645_RS07360 1572575..1573276 - 702 WP_152221359.1 ATP-binding cassette domain-containing protein -
GA645_RS07365 1573280..1574047 - 768 WP_152221361.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
GA645_RS07370 1574044..1575300 - 1257 WP_152221363.1 high-affinity branched-chain amino acid ABC transporter permease LivM -
GA645_RS07375 1575297..1576220 - 924 WP_152221365.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14732.95 Da        Isoelectric Point: 6.8615

>T141243 WP_152221355.1 NZ_CP045118:c1572207-1571803 [Pseudomonas sp. SCB32]
MLKYLLDTNICIFTIKNKPQAVRDAFNRHHGQLCISSVTLMELIYGAEKSAAPERNLAVVEGFAARLDVLPYDASAAAHT
GQLRTELARAGTPIGPYDQMIAGHARSLGLILVSNDLREFERVPGLRLEDWASV

Download         Length: 405 bp

>T141243 NZ_CP059907:c190825-190652 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8511.33 Da        Isoelectric Point: 4.1834

>AT141243 WP_152221357.1 NZ_CP045118:c1572437-1572207 [Pseudomonas sp. SCB32]
MDQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRTRIISPAGESWDSWFDGEDVSQDFMADREQPAEQEREGF

Download         Length: 231 bp

>AT141243 NZ_CP059907:c191149-190853 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References