Detailed information of TA system TA141242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1344863..1345479
• Replicon: chromosome
• Accession: NZ_CP045118
• Organism: Pseudomonas sp. SCB32

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GA645_RS06240
• Protein ID: WP_152220946.1
• Coordinates: 1345183..1345479 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GA645_RS06235
• Protein ID: WP_152220944.1
• Coordinates: 1344863..1345186 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA645_RS06210	1340208..1340855	-	648	WP_152220934.1	ferric reductase-like transmembrane domain-containing protein	-
GA645_RS06215	1340995..1342305	-	1311	WP_152220936.1	HAMP domain-containing histidine kinase	-
GA645_RS06220	1342302..1343042	-	741	WP_152220938.1	response regulator	-
GA645_RS06225	1343267..1343539	+	273	WP_152220940.1	DUF2790 domain-containing protein	-
GA645_RS06230	1343604..1344824	+	1221	WP_152220942.1	cytochrome c biogenesis protein DipZ	-
GA645_RS06235	1344863..1345186	-	324	WP_152220944.1	putative addiction module antidote protein	Antitoxin
GA645_RS06240	1345183..1345479	-	297	WP_152220946.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GA645_RS06245	1345624..1346265	-	642	WP_152220948.1	DUF1109 domain-containing protein	-
GA645_RS06250	1346252..1346839	-	588	WP_152220950.1	sigma-70 family RNA polymerase sigma factor	-
GA645_RS06255	1347072..1347356	+	285	WP_152220951.1	DUF2282 domain-containing protein	-
GA645_RS06260	1347391..1348206	+	816	WP_152227945.1	DUF692 domain-containing protein	-
GA645_RS06265	1348203..1348958	+	756	WP_152220953.1	DNA-binding domain-containing protein	-
GA645_RS06270	1348970..1349431	+	462	WP_152220955.1	DoxX family protein	-
GA645_RS06275	1349440..1350084	-	645	WP_152220957.1	PQQ-binding-like beta-propeller repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (5-96)

Antitoxin

• Uncharacterized protein HI1420 (7-96)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10949.71 Da
• Isoelectric Point: 10.6086

>T141242 WP_152220946.1 NZ_CP045118:c1345479-1345183 [Pseudomonas sp. SCB32]
MTYLIKQTDIFGRWLAGLRDVQSKVAILRRMERIRSGNLGDARSVGVGVSELRLDIGPGYRVYFTRRGNVVIVLLCGGDK
SSQQRDIKLAQQLAGEIE

Nucleotide

• Length: 297 bp

>T141242 NZ_CP059903:948325-948726 [Nocardioides sp. S-713]
GTGCCTGAGGGGACGACGTCCGGTGCGGTCGTCGACGCCTCGGCCCTCGTGGATCTCCTGGCGGGGACGGAGCTGGCCGG
AGCGGTACGAGCGCGCCTCGCCGGCCTGGTGCTCCACGCGCCGGCCCACCTGGACGTGGAGTGCCTGTCGGCGCTGGGAC
GCCTGCATCGCGCAGAACTCCTGACGAGTGCCCAGGTCTCGACGGCGCTGTCCGACCTGGCCGAGGCGCCCCTCCTGCGG
CATCCCCTCCCGCCGCTGCTGGCCGGCGCGTGGTCTCGCAGGGAGAACCTCCGGTTGGCGGACTCCCTGTACGTCGAGCT
CGCCGAGCATCTCGGCCTCCCGGTGGTCACCACCGACGCTCGGCTGGCGCGTGGCGCTGCCCGGGTCGCGCTGATCGGCT
GA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11540.15 Da
• Isoelectric Point: 4.5112

>AT141242 WP_152220944.1 NZ_CP045118:c1345186-1344863 [Pseudomonas sp. SCB32]
MTLELREFDTSAYLDNEEVIAEYLSQVLADGDSDELLVAIGNIAKARGMTKIANDSGLGRESLYKVFAPGAKPRFETVMK
VMRALGVELQAKPLAAGKSYGNLPSSD

Nucleotide

• Length: 324 bp

>AT141242 NZ_CP059903:948114-948332 [Nocardioides sp. S-713]
ATGGCACGCCTGAACGTCTACGTCCCCGACGAGCTGGCGGCAGCAGCCCGCGACGCAGGCCTGAACGTCTCGGCGCTGAC
CCAGCAGGCACTCTCGGATGCGCTCTCGCGGGCGGCCACGGACTCGTGGCTCGCGCGGATCGATCGCCCGGTATCGGCCG
CCACCCACGCTGCCGTGGCGGCAGCACTGGACGCAGCCCGGGACGAGCTCGGTGCCTGA