Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3544945..3545598 Replicon chromosome
Accession NZ_CP045110
Organism Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)


Gene name cptA Uniprot ID D0CD27
Locus tag FQU82_RS17020 Protein ID WP_000607073.1
Coordinates 3544945..3545334 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag FQU82_RS17025 Protein ID WP_001288210.1
Coordinates 3545341..3545598 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU82_RS17005 3540065..3542260 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
FQU82_RS17010 3542448..3543014 - 567 WP_000651536.1 rhombosortase -
FQU82_RS17015 3543093..3544175 - 1083 WP_000049103.1 hypothetical protein -
FQU82_RS17020 3544945..3545334 - 390 WP_000607073.1 membrane protein Toxin
FQU82_RS17025 3545341..3545598 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
FQU82_RS17030 3545786..3546958 + 1173 WP_001190553.1 acyl-CoA dehydrogenase family protein -
FQU82_RS17035 3547008..3548498 - 1491 WP_000415127.1 NAD(P)/FAD-dependent oxidoreductase -
FQU82_RS17040 3548680..3549057 - 378 WP_001216380.1 50S ribosomal protein L17 -
FQU82_RS17045 3549076..3550083 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T141239 WP_000607073.1 NZ_CP045110:c3545334-3544945 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T141239 NZ_CP059901:169037-169339 [Mumia sp. ZJ1417]
ATGCGACCGATCCACGTGGCCCGTCTCGACAAGGCGCGGCCGGTGCTGGTTCTTACCCGTGAGGTCGTTCGTCCGTATCT
GAATCGGGTCACCGTCGCGCCGATTACGAGTACGATCCGCGGGCTCTCCACCGAAGTTCCTGTCGGTCCGATCAATGGCC
TTGACCGCGACAGCGTGGTGAGCTGCGACAACATCGTGACTGTGCCCGTGGAAAGTGTGGGCCGACAGCTCGGCTTCCTG
CTCGAGTCGCAGGAGGGCGACCTCGCGCATGCGATCCGCGCTGCGTTCGACCTCGATCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT141239 WP_001288210.1 NZ_CP045110:c3545598-3545341 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT141239 NZ_CP059901:168801-169037 [Mumia sp. ZJ1417]
ATGAGCACTCAGATCGCTGTGCGTCTGGACGACGATCTCGTGACGTTCGTGGACGAGCTGGTCAAAGCGGGCGAGGCCCC
GAGTCGCGCTGCCGTCGTGACGCAGGCGCTCCAGCGGGAGCAGCGACGCACGGTTGCTGAACGCGACGCTGCGATTCTTG
CCGCTGAACGGGAAGACACTGACATGGACGGGCTGGCGGAGTTCGCGGCCGGCGTGTCGATGGACGACCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0CD27

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References