Detailed information of TA system TA141232

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2944810..2945459
• Replicon: chromosome
• Accession: NZ_CP045101
• Organism: Acinetobacter johnsonii strain AJ210

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E1ZP63
• Locus tag: GBN68_RS14330
• Protein ID: WP_062032505.1
• Coordinates: 2944810..2945196 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: GBN68_RS14335
• Protein ID: WP_004977895.1
• Coordinates: 2945202..2945459 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBN68_RS14315 (GBN68_14335)	2940143..2942425	-	2283	WP_234954337.1	TRAP transporter large permease subunit	-
GBN68_RS14320 (GBN68_14340)	2942608..2943180	-	573	WP_201706810.1	rhombosortase	-
GBN68_RS14325	2943252..2944289	-	1038	WP_234954339.1	hypothetical protein	-
GBN68_RS14330 (GBN68_14350)	2944810..2945196	-	387	WP_062032505.1	hypothetical protein	Toxin
GBN68_RS14335 (GBN68_14355)	2945202..2945459	-	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
GBN68_RS14340 (GBN68_14360)	2945652..2946824	+	1173	WP_234954341.1	acyl-CoA dehydrogenase family protein	-
GBN68_RS14345 (GBN68_14365)	2946860..2947651	-	792	WP_234954343.1	alpha/beta hydrolase	-
GBN68_RS14350 (GBN68_14370)	2947789..2949279	-	1491	WP_148825439.1	NAD(P)/FAD-dependent oxidoreductase	-
GBN68_RS14355 (GBN68_14375)	2949475..2949840	-	366	WP_004691290.1	50S ribosomal protein L17	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15316.31 Da
• Isoelectric Point: 10.4419

>T141232 WP_062032505.1 NZ_CP045101:c2945196-2944810 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGLWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T141232 NZ_CP059900:2464144-2464536 [Tomitella sp. HY172]
GTGAGCGACCACCTCGACCGTGAGGATGTCCTGCACGCGGGGTCGATCGCGGTCGGACACCGCCTCGACGTCCGTGACTA
CGGCCTCTTGGATGCGGCGGTCGCTCGTCCGCGCGCAACGGTGTTCGGCATCGACGCCTACGAGGGCGATTTCGAGAAAG
CGGCAGCACTGCTGCAGTCGCTGGCCCGCAACCATGCGTTCGTCGATGGCAACAAGCGCACAGCGTGGGCCTCAGCTTGG
GTATTCCTGCATCTGAACGGGCATGAGCTGGACCCTTCGTTCGATGTGGACGGCGCCGAAGCCTTCATGGAGCAGGCCGC
CACGCACTCAGAAATGGAAGTCCCGCAACTCGCATCCCGTCTCCGTGGCTTCGCCCTGTCTGCCGACGACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT141232 WP_004977895.1 NZ_CP045101:c2945459-2945202 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT141232 NZ_CP059900:2463950-2464147 [Tomitella sp. HY172]
ATGCCAGCGCTGAATGTCCCTTTCACAGACGATGAGATGGAAGCAGTGCGCGCGGGCGCCGCCGAAGCCGAGCAATCGCT
GCGCATGTTCGCTCACGACGCCGTCCTGAGCGCTGCCGATCAGCATAAGAAGCGTGTGCGCGAAGCGGCCGCCCTCATCG
CGAGCCGGTCCAGCGAACTCAACCGTCGTCTCGCGTGA

Structures

Antitoxin

• AlphaFold DB: N9CU98