Detailed information of TA system TA141230

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 417100..417749
• Replicon: chromosome
• Accession: NZ_CP045099
• Organism: Acinetobacter johnsonii strain AJ14

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E1ZP63
• Locus tag: F9230_RS01960
• Protein ID: WP_062032505.1
• Coordinates: 417363..417749 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: F9230_RS01955
• Protein ID: WP_004977895.1
• Coordinates: 417100..417357 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9230_RS01935 (F9230_01940)	412719..413084	+	366	WP_004691290.1	50S ribosomal protein L17	-
F9230_RS01940 (F9230_01945)	413280..414770	+	1491	WP_234951096.1	NAD(P)/FAD-dependent oxidoreductase	-
F9230_RS01945 (F9230_01950)	414909..415700	+	792	WP_234951097.1	alpha/beta hydrolase	-
F9230_RS01950 (F9230_01955)	415735..416907	-	1173	WP_234951098.1	acyl-CoA dehydrogenase family protein	-
F9230_RS01955 (F9230_01960)	417100..417357	+	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
F9230_RS01960 (F9230_01965)	417363..417749	+	387	WP_062032505.1	hypothetical protein	Toxin
F9230_RS01965 (F9230_01975)	418270..419307	+	1038	WP_218288529.1	hypothetical protein	-
F9230_RS01970 (F9230_01980)	419379..419951	+	573	WP_218288528.1	rhombosortase	-
F9230_RS01975 (F9230_01985)	420134..422416	+	2283	WP_062032499.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15316.31 Da
• Isoelectric Point: 10.4419

>T141230 WP_062032505.1 NZ_CP045099:417363-417749 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGLWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T141230 NZ_CP059900:1767879-1768151 [Tomitella sp. HY172]
GTGACGGGCTGGCAACTCCGAACCACCACCAGGTTCGATAGAGCAGCCCGAAAACTCGATCGACAGGTCCTGCGGCGGGT
GCGGACGTATCTGGACGAGGTGTGCCAGCTCGATGACCCGCGACTTCGCGGCAAGCCGCTCACCGCTGGACTATCCGGGT
ACTGGCGATATCGCATTGGTGATTGGCGTGTGATCGCTGAAATTCGTGAATCGGAACTGATTGTTCTCGCAATCGGCCTC
GGCCATAGGTCCGAAATTTACGGCAACGACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT141230 WP_004977895.1 NZ_CP045099:417100-417357 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT141230 NZ_CP059900:1767661-1767882 [Tomitella sp. HY172]
TTGTCCATGTCGATCAGGCTCACATCGGAGGAAGAGGCACGTTTGGATCGTCTTGCCAAACGCACCGGCCGTTCGAAGTC
GTTCTATGTGCGCGAGGCGCTTCGGGAGCACCTCGACGAGTTGGAAGAGAAGTACTGGGGGGATGCCGTCGTGCAGGAGT
GGGAAGCATCGGACAAGACGAGCCGGCCGGCCCAGGAACTCTGGGATGAGCTGGGGGTGTGA

Structures

Antitoxin

• AlphaFold DB: N9CU98