Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3045938..3046491 Replicon chromosome
Accession NZ_CP045098
Organism Pectobacterium carotovorum strain ZM1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GBN63_RS13560 Protein ID WP_161528562.1
Coordinates 3046177..3046491 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GBN63_RS13555 Protein ID WP_010305008.1
Coordinates 3045938..3046174 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBN63_RS13545 (GBN63_13620) 3044152..3045045 - 894 Protein_2620 IS3 family transposase -
GBN63_RS13550 (GBN63_13625) 3045409..3045795 + 387 Protein_2621 ArdC family protein -
GBN63_RS13555 (GBN63_13630) 3045938..3046174 + 237 WP_010305008.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GBN63_RS13560 (GBN63_13635) 3046177..3046491 + 315 WP_161528562.1 CcdB family protein Toxin
GBN63_RS13565 (GBN63_13640) 3046704..3046991 - 288 WP_010305018.1 hypothetical protein -
GBN63_RS13570 (GBN63_13645) 3047704..3048606 - 903 WP_039536805.1 AraC family transcriptional regulator -
GBN63_RS13575 (GBN63_13650) 3048825..3049418 + 594 WP_203470163.1 NAD(P)H-dependent oxidoreductase -
GBN63_RS13580 (GBN63_13655) 3049473..3050441 + 969 WP_239766369.1 Gfo/Idh/MocA family oxidoreductase -
GBN63_RS13585 (GBN63_13660) 3050835..3051464 + 630 WP_234932181.1 flavodoxin/nitric oxide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3044878..3045045 167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11510.48 Da        Isoelectric Point: 6.9727

>T141229 WP_161528562.1 NZ_CP045098:3046177-3046491 [Pectobacterium carotovorum]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVMLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGF

Download         Length: 315 bp

>T141229 NZ_CP059900:1252734-1253147 [Tomitella sp. HY172]
GTGACGCGGGCGCCGTGGCTGATCGACAAGTCAGCATTGGTACGCATGCCGGATTCGCGCGATGTCGACGAATGGAACAA
TCGGGTTCGGCGCGGCCTCGTCCGCATCGCCACGGTGACCTTGTTGGAGGTGGGCTACTCCGCGCGCTCTGCGGAGGGGC
ACCGGAGCGCATTGACCACCGCGCCGATCGCCCTTATGCCCGTCGAGCACGCGACTCCCGCCGCCGAGCGCCGTGCCGTC
GAGGTCCAGGGGATGCTGGCGGCACGCGGGCATCACCGGGGCCCGTCGGTGCCGGACCTGATCATCGCGGCCGTTGCCGA
GCACGCGCGCCTCACCGTGCTGCATGTGGACAGGGACTTCGAACTGATCGCCGAGGTCACCGGTCAGCCCGTCGCCCGTC
TGGCGGTGTCATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8934.00 Da        Isoelectric Point: 7.1672

>AT141229 WP_010305008.1 NZ_CP045098:3045938-3046174 [Pectobacterium carotovorum]
MTAKPRNTQSVTITVERALLVRAREAGINLSATLSTALDAELRRHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT141229 NZ_CP059900:1252513-1252737 [Tomitella sp. HY172]
ATGGCCGATATCCTTATTCGCGGGTTGGACGAGGCGACGGTGGCGGAGATCGACCGTCGTGCGGCGGAGAGCGGGCAGTC
GCGGGCGGAATTCTTGCGGCGACGGCTCGACGTGGAGTTCCGGTCCGGCACGGACATCCCTGTCACGGTGGACGACTGGC
GCAGGTTCGGCGCTGCGGCGGCGGACCTGGGCGATCCCTCCGTGATGGGGGAGGCCTGGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References