Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2576960..2577585 Replicon chromosome
Accession NZ_CP045098
Organism Pectobacterium carotovorum strain ZM1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag GBN63_RS11555 Protein ID WP_005976087.1
Coordinates 2576960..2577163 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag GBN63_RS11560 Protein ID WP_005976089.1
Coordinates 2577217..2577585 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBN63_RS11525 (GBN63_11585) 2572420..2572758 + 339 WP_002208627.1 P-II family nitrogen regulator -
GBN63_RS11530 (GBN63_11590) 2572798..2574084 + 1287 WP_039472387.1 ammonium transporter AmtB -
GBN63_RS11535 (GBN63_11595) 2574219..2575082 - 864 WP_239765982.1 acyl-CoA thioesterase II -
GBN63_RS11540 (GBN63_11600) 2575295..2575876 + 582 WP_010303016.1 YbaY family lipoprotein -
GBN63_RS11545 (GBN63_11605) 2575896..2576216 - 321 WP_015839360.1 MGMT family protein -
GBN63_RS11555 (GBN63_11615) 2576960..2577163 - 204 WP_005976087.1 HHA domain-containing protein Toxin
GBN63_RS11560 (GBN63_11620) 2577217..2577585 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
GBN63_RS11565 (GBN63_11625) 2578184..2578327 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
GBN63_RS11570 (GBN63_11630) 2578345..2578593 - 249 WP_010303021.1 type B 50S ribosomal protein L31 -
GBN63_RS11575 (GBN63_11635) 2578812..2581940 - 3129 WP_010303023.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T141227 WP_005976087.1 NZ_CP045098:c2577163-2576960 [Pectobacterium carotovorum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T141227 NZ_CP059898:c4421216-4420938 [Streptomyces sp. M54]
ATGGGTCACGCCACACGATTCACACCGCACGCGCAGCGGGACCTTCTCAAGATTCCGTTGCCGGAAGCCCGCCGCATCCT
CGGCCGCCTGGCGGATCTCCAGAAGGCGCTGGACGCGGAGGACCTCGCCGGATTCGACGTCAAACCGCTCCAGGGCCATG
ACGCACGCTGGCGTCTCCGCGTGGGCGACTACCGGGCCGTCTACACCGTGGAGGACGGGCGGCTCATCGTCTGGGTGCTA
GCCGTCGGCCATCGGCGCGAGATCTATCGAGCCTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT141227 WP_005976089.1 NZ_CP045098:c2577585-2577217 [Pectobacterium carotovorum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT141227 NZ_CP059898:c4421498-4421220 [Streptomyces sp. M54]
ATGAGTGAGCCCGTGACCGAGTCCATGGCAGAGGTGCGCAAGCACCTCGCGGACGTCATCGACCGCGCCCGCCGTGACGA
GACGCCCACGATCATCACCCGCCGAGGCAAGAGCGAAGCGGTCCTCGTCGACATCGACGAGTATCGGCGTCTGCGCGAGA
CCGCCGAGCGGTACGAGGACGAATGGCTCAACCGGCTCGCGGACAAAGCGGAGGCCGAAGGAACCAACGGATCGGTATCC
CTCGAAGAGATGGCCGCGCTCCTCCGGTCGGCCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References