Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1819612..1820195 Replicon chromosome
Accession NZ_CP045098
Organism Pectobacterium carotovorum strain ZM1

Toxin (Protein)


Gene name parE Uniprot ID A0A7V8PTK4
Locus tag GBN63_RS08225 Protein ID WP_010296214.1
Coordinates 1819890..1820195 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V8PT23
Locus tag GBN63_RS08220 Protein ID WP_010296210.1
Coordinates 1819612..1819902 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBN63_RS08200 (GBN63_08210) 1814746..1816008 - 1263 WP_010296200.1 L-rhamnose isomerase -
GBN63_RS08205 (GBN63_08215) 1816005..1817495 - 1491 WP_039507368.1 rhamnulokinase -
GBN63_RS08210 (GBN63_08220) 1817832..1818671 + 840 WP_039493893.1 HTH-type transcriptional activator RhaS -
GBN63_RS08215 (GBN63_08225) 1818696..1819550 + 855 WP_039507370.1 helix-turn-helix domain-containing protein -
GBN63_RS08220 (GBN63_08230) 1819612..1819902 + 291 WP_010296210.1 ribbon-helix-helix protein, CopG family Antitoxin
GBN63_RS08225 (GBN63_08235) 1819890..1820195 + 306 WP_010296214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GBN63_RS08230 (GBN63_08240) 1820315..1822021 - 1707 WP_239768055.1 ABC transporter ATP-binding protein -
GBN63_RS08235 (GBN63_08245) 1822018..1822884 - 867 WP_010296221.1 ABC transporter permease -
GBN63_RS08240 (GBN63_08250) 1822877..1823836 - 960 WP_039470517.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11576.44 Da        Isoelectric Point: 9.8325

>T141223 WP_010296214.1 NZ_CP045098:1819890-1820195 [Pectobacterium carotovorum]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTGRVVILTVKHQKEAGYQNP

Download         Length: 306 bp

>T141223 NZ_CP059897:c822886-822482 [Ciceribacter thiooxidans]
GTGATCTCGCATCTTCTCGACACCAACACCGTTATTGCCTTGATCGGCCGCAAGTCAAACGCCTTGGTAAGCCGTGTACT
CCACAGCCCTCAGGGCAGTATCGGCCTGCCGACGGTCGTCGCGTATGAACTCTATTTCGGAGCGCAGAAAAGCGCGAAGG
TCCAGCACAACCTGGAAACCTTGCGTTTGTTTATGGCAGATTTTCCGATCCTTGAGTTTGACCGGAACGATGCCTTTGTC
GCAGGCGAAATCCGGGCGGCCCTTGCCGCGAAGGGGACGCCCATCGGCCCCTATGACGTGCTGATCGCGGGGCAGGCGAA
GGCCCGCGGACTAACTCTCGTCACCAACAATGTCGGCGAATTCAACAGGGTTGACAACCTGCATGTGGAAGACTGGTCGC
TTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11064.13 Da        Isoelectric Point: 4.7692

>AT141223 WP_010296210.1 NZ_CP045098:1819612-1819902 [Pectobacterium carotovorum]
MADTTRQTTTLRIDQDIKERLKTLADDRNSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEDYQDTGKHITADETVTWL
ESWGSGHEQDAPACHK

Download         Length: 291 bp

>AT141223 NZ_CP059897:c823143-822883 [Ciceribacter thiooxidans]
ATGCCCCATTTTGCACGCGTATTCCAGTCCGGAAACTCGCAGGCCGTCCGCCTGCCGAAGGAATTCCGCTTCAACGTCGA
GCGCGTGGAGATCACGCAGGAGGGCGATGCGCTCATTCTCCGTCCCCATGTCGAGGCGGGCGAGCCGTGGTCGTCGCTGA
AAGCAGCGCTGGCCCGCGGCATGAGTGAAGACTTCATGGAGAGCGGGCGCGAGCAGCCTGAACAGCAGGATCGACCGGAG
CTTGACGCGGTGTTTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8PTK4

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8PT23

References