Detailed information of TA system TA141220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1385211..1385746
• Replicon: chromosome
• Accession: NZ_CP045098
• Organism: Pectobacterium carotovorum strain ZM1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GBN63_RS06215
• Protein ID: WP_239767891.1
• Coordinates: 1385211..1385498 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A837DL69
• Locus tag: GBN63_RS06220
• Protein ID: WP_010296546.1
• Coordinates: 1385495..1385746 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBN63_RS06195 (GBN63_06205)	1380649..1382004	+	1356	WP_010296534.1	alkyl/aryl-sulfatase	-
GBN63_RS06200 (GBN63_06210)	1382127..1382510	+	384	WP_039508339.1	TfoX/Sxy family protein	-
GBN63_RS06205 (GBN63_06215)	1382792..1383634	+	843	WP_010296540.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
GBN63_RS06210 (GBN63_06220)	1383763..1385115	+	1353	WP_010296544.1	glutathione-disulfide reductase	-
GBN63_RS06215 (GBN63_06225)	1385211..1385498	-	288	WP_239767891.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GBN63_RS06220 (GBN63_06230)	1385495..1385746	-	252	WP_010296546.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GBN63_RS06225 (GBN63_06235)	1386004..1386909	+	906	WP_029367632.1	siderophore-interacting protein	-
GBN63_RS06230 (GBN63_06240)	1386944..1387699	-	756	WP_039542415.1	thiol:disulfide interchange protein DsbG	-
GBN63_RS06235 (GBN63_06245)	1387978..1388601	+	624	WP_161509986.1	LysE family translocator	-
GBN63_RS06240 (GBN63_06250)	1388846..1389283	-	438	WP_010296551.1	RICIN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11090.21 Da
• Isoelectric Point: 10.3527

>T141220 WP_239767891.1 NZ_CP045098:c1385498-1385211 [Pectobacterium carotovorum]
MSYSVKFREDALKEWLKLDKAIQQQFAKKLKKCCENPHIPAAKLRGMKDCYKIKLRTSGFRLVYEVIDDVLIIAMVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T141220 NZ_CP059892:9583-9897 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9131.50 Da
• Isoelectric Point: 4.0785

>AT141220 WP_010296546.1 NZ_CP045098:c1385746-1385495 [Pectobacterium carotovorum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVEVDLD
SFL

Nucleotide

• Length: 252 bp

>AT141220 NZ_CP059892:9317-9595 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837DL69