Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 1086690..1088275 | Replicon | chromosome |
| Accession | NZ_CP045098 | ||
| Organism | Pectobacterium carotovorum strain ZM1 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | GBN63_RS04950 | Protein ID | WP_239767770.1 |
| Coordinates | 1086956..1088275 (+) | Length | 440 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | GBN63_RS04945 | Protein ID | WP_039475230.1 |
| Coordinates | 1086690..1086956 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GBN63_RS04920 (GBN63_04920) | 1082323..1083825 | - | 1503 | WP_239767766.1 | MFS transporter | - |
| GBN63_RS04925 (GBN63_04925) | 1083929..1084483 | + | 555 | WP_239767768.1 | TetR/AcrR family transcriptional regulator | - |
| GBN63_RS04930 (GBN63_04930) | 1084533..1084943 | - | 411 | WP_117625006.1 | helix-turn-helix domain-containing protein | - |
| GBN63_RS04935 (GBN63_04935) | 1085058..1085909 | + | 852 | WP_039475225.1 | SDR family oxidoreductase | - |
| GBN63_RS04940 (GBN63_04940) | 1085966..1086529 | - | 564 | WP_203470601.1 | hypothetical protein | - |
| GBN63_RS04945 (GBN63_04945) | 1086690..1086956 | + | 267 | WP_039475230.1 | helix-turn-helix domain-containing protein | Antitoxin |
| GBN63_RS04950 (GBN63_04950) | 1086956..1088275 | + | 1320 | WP_239767770.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| GBN63_RS04955 (GBN63_04955) | 1088432..1089796 | - | 1365 | WP_010302387.1 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE | - |
| GBN63_RS04960 (GBN63_04960) | 1089925..1091559 | - | 1635 | WP_161503023.1 | membrane protein insertase YidC | - |
| GBN63_RS04965 (GBN63_04965) | 1091562..1091819 | - | 258 | WP_010281237.1 | membrane protein insertion efficiency factor YidD | - |
| GBN63_RS04970 (GBN63_04970) | 1091783..1092142 | - | 360 | WP_010302382.1 | ribonuclease P protein component | - |
| GBN63_RS04975 (GBN63_04975) | 1092161..1092301 | - | 141 | WP_005976668.1 | 50S ribosomal protein L34 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 440 a.a. Molecular weight: 49186.28 Da Isoelectric Point: 6.5027
>T141218 WP_239767770.1 NZ_CP045098:1086956-1088275 [Pectobacterium carotovorum]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRVVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGTDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILVEFSNTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRVVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGTDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILVEFSNTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE
Download Length: 1320 bp
>T141218 NZ_CP059891:c115636-115220 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9917.18 Da Isoelectric Point: 9.7281
>AT141218 WP_039475230.1 NZ_CP045098:1086690-1086956 [Pectobacterium carotovorum]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEASV
ASSWKEEW
Download Length: 267 bp
>AT141218 NZ_CP059891:c115863-115633 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|