Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 420833..421473 Replicon chromosome
Accession NZ_CP045098
Organism Pectobacterium carotovorum strain ZM1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag GBN63_RS01955 Protein ID WP_239767484.1
Coordinates 420833..421249 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag GBN63_RS01960 Protein ID WP_010295083.1
Coordinates 421246..421473 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBN63_RS01935 (GBN63_01935) 416358..417344 - 987 WP_201963398.1 quinone oxidoreductase -
GBN63_RS01940 (GBN63_01940) 417592..418998 + 1407 WP_010295074.1 replicative DNA helicase -
GBN63_RS01945 (GBN63_01945) 419040..420122 + 1083 WP_239767480.1 alanine racemase -
GBN63_RS01950 (GBN63_01950) 420115..420753 + 639 WP_239767482.1 hypothetical protein -
GBN63_RS01955 (GBN63_01955) 420833..421249 - 417 WP_239767484.1 type II toxin-antitoxin system VapC family toxin Toxin
GBN63_RS01960 (GBN63_01960) 421246..421473 - 228 WP_010295083.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GBN63_RS01965 (GBN63_01965) 422926..423405 + 480 WP_239767486.1 Lrp/AsnC family transcriptional regulator -
GBN63_RS01970 (GBN63_01970) 423655..424269 + 615 WP_010295088.1 YitT family protein -
GBN63_RS01975 (GBN63_01975) 424333..425526 + 1194 WP_239767487.1 amino acid aminotransferase -
GBN63_RS01980 (GBN63_01980) 425695..426198 + 504 WP_039507077.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15246.85 Da        Isoelectric Point: 8.7720

>T141217 WP_239767484.1 NZ_CP045098:c421249-420833 [Pectobacterium carotovorum]
VSRLFMLDTNICSFIMREHPAEVIEKLQQCMLRRDRIVVSAITYAEMRFGAVGKKASPRHMQLVDAFCRRLDAVLPWDSA
AVDATTKIKIALAAAGTPIGPNDTAIAGHAISAKAILVTNNLREFERVPGLTLEDWVK

Download         Length: 417 bp

>T141217 NZ_CP059891:c41082-40600 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8908.08 Da        Isoelectric Point: 4.5216

>AT141217 WP_010295083.1 NZ_CP045098:c421473-421246 [Pectobacterium carotovorum]
MRIVSVFKNGNNRAIRLPRDMDFEGVNELEIVREGDTIMLRPIKPNWHSFLQEERADADFMTERQDVVEEGRFEL

Download         Length: 228 bp

>AT141217 NZ_CP059891:c41336-41070 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References