Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2255664..2256300 Replicon chromosome
Accession NZ_CP045097
Organism Pectobacterium carotovorum strain RC5297

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F9W95_RS09975 Protein ID WP_103941744.1
Coordinates 2255664..2255846 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F9W95_RS09980 Protein ID WP_107332493.1
Coordinates 2255869..2256300 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9W95_RS09950 (F9W95_10010) 2251032..2251235 + 204 WP_005976130.1 YbdD/YjiX family protein -
F9W95_RS09955 (F9W95_10015) 2251252..2252238 + 987 WP_103860134.1 GTPase -
F9W95_RS09960 (F9W95_10020) 2252504..2253886 + 1383 WP_103941748.1 glycosyl hydrolase family 28 protein -
F9W95_RS09965 (F9W95_10025) 2254120..2254599 - 480 WP_103860136.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
F9W95_RS09970 (F9W95_10030) 2254670..2255488 - 819 WP_107332492.1 TraB/GumN family protein -
F9W95_RS09975 (F9W95_10035) 2255664..2255846 + 183 WP_103941744.1 type II toxin-antitoxin system HicA family toxin Toxin
F9W95_RS09980 (F9W95_10040) 2255869..2256300 + 432 WP_107332493.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F9W95_RS09985 (F9W95_10045) 2256395..2259118 - 2724 WP_233972851.1 copper-exporting P-type ATPase CopA -
F9W95_RS09990 (F9W95_10050) 2259234..2259641 + 408 WP_107332495.1 Cu(I)-responsive transcriptional regulator -
F9W95_RS09995 (F9W95_10055) 2259677..2260132 - 456 WP_103970633.1 NfeD family protein -
F9W95_RS10000 (F9W95_10060) 2260132..2261046 - 915 WP_010301277.1 SPFH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6512.68 Da        Isoelectric Point: 10.3299

>T141214 WP_103941744.1 NZ_CP045097:2255664-2255846 [Pectobacterium carotovorum]
MTSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Download         Length: 183 bp

>T141214 NZ_CP059889:c5301989-5301606 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16036.95 Da        Isoelectric Point: 4.3145

>AT141214 WP_107332493.1 NZ_CP045097:2255869-2256300 [Pectobacterium carotovorum]
MFFSVGVETPKDDATAYGLIVPALCTDDYGCFSAADSQQEIARMAREAILTLIDEAVSRGNLDIKRLNDAGHLIYAAIPD
FADYDSWFVLDVDLSAFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Download         Length: 432 bp

>AT141214 NZ_CP059889:c5302231-5301989 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References