Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1952551..1953329 Replicon chromosome
Accession NZ_CP045097
Organism Pectobacterium carotovorum strain RC5297

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag F9W95_RS08700 Protein ID WP_233972555.1
Coordinates 1952841..1953329 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag F9W95_RS08695 Protein ID WP_019844370.1
Coordinates 1952551..1952844 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9W95_RS08660 (F9W95_08705) 1948421..1948828 + 408 WP_039490298.1 hypothetical protein -
F9W95_RS08665 (F9W95_08710) 1948867..1950279 + 1413 WP_109225476.1 DUF4832 domain-containing protein -
F9W95_RS08670 (F9W95_08715) 1950306..1950806 + 501 WP_103861241.1 serine acetyltransferase -
F9W95_RS08675 (F9W95_08720) 1951013..1951299 + 287 Protein_1687 DUF1778 domain-containing protein -
F9W95_RS08680 (F9W95_08730) 1951420..1951638 - 219 WP_180783082.1 type II toxin-antitoxin system antitoxin CcdA -
F9W95_RS08685 (F9W95_08735) 1951653..1951901 - 249 WP_010299606.1 helix-turn-helix transcriptional regulator -
F9W95_RS08690 (F9W95_08740) 1951908..1952050 + 143 Protein_1690 helix-turn-helix domain-containing protein -
F9W95_RS08695 (F9W95_08745) 1952551..1952844 + 294 WP_019844370.1 DUF1778 domain-containing protein Antitoxin
F9W95_RS08700 (F9W95_08750) 1952841..1953329 + 489 WP_233972555.1 GNAT family N-acetyltransferase Toxin
F9W95_RS08705 (F9W95_08760) 1954190..1955215 - 1026 WP_120358785.1 IS630 family transposase -
F9W95_RS08710 (F9W95_08765) 1955266..1955505 - 240 WP_240004672.1 RloB family protein -
F9W95_RS08715 (F9W95_08770) 1955505..1956833 - 1329 WP_233972554.1 ATP-binding protein -
F9W95_RS08720 (F9W95_08775) 1957082..1957387 - 306 WP_233972553.1 type II toxin-antitoxin system toxin CcdB -
F9W95_RS08725 (F9W95_08780) 1957390..1957608 - 219 WP_015855076.1 type II toxin-antitoxin system antitoxin CcdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1936734..1961446 24712
- flank IS/Tn - - 1954190..1955215 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(76-143)

Antitoxin

Vibrio phage ICP1, Orf50

(5-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17453.26 Da        Isoelectric Point: 7.8051

>T141211 WP_233972555.1 NZ_CP045097:1952841-1953329 [Pectobacterium carotovorum]
MISAPEPLHAEHVLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDGSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVG
SL

Download         Length: 489 bp

>T141211 NZ_CP059889:c4722770-4722237 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10884.50 Da        Isoelectric Point: 10.1968

>AT141211 WP_019844370.1 NZ_CP045097:1952551-1952844 [Pectobacterium carotovorum]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT141211 NZ_CP059889:c4723047-4722781 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References