Detailed information of TA system TA141209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1783812..1784337
• Replicon: chromosome
• Accession: NZ_CP045097
• Organism: Pectobacterium carotovorum strain RC5297

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9W95_RS07930
• Protein ID: WP_233962148.1
• Coordinates: 1783812..1784096 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: F9W95_RS07935
• Protein ID: WP_005973616.1
• Coordinates: 1784086..1784337 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9W95_RS07900 (F9W95_07940)	1779338..1779763	+	426	WP_130621938.1	hypothetical protein	-
F9W95_RS07905 (F9W95_07945)	1780013..1780495	+	483	WP_029367525.1	GNAT family N-acetyltransferase	-
F9W95_RS07910 (F9W95_07950)	1780541..1781167	-	627	WP_103861356.1	LysE family transporter	-
F9W95_RS07915 (F9W95_07955)	1781423..1782205	-	783	WP_103861355.1	transporter substrate-binding domain-containing protein	-
F9W95_RS07920 (F9W95_07960)	1782574..1783152	-	579	WP_240004654.1	hypothetical protein	-
F9W95_RS07925	1783370..1783546	-	177	WP_158256803.1	hypothetical protein	-
F9W95_RS07930 (F9W95_07965)	1783812..1784096	-	285	WP_233962148.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9W95_RS07935 (F9W95_07970)	1784086..1784337	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
F9W95_RS07940	1784509..1784760	-	252	WP_223193489.1	hypothetical protein	-
F9W95_RS07945 (F9W95_07980)	1784750..1785001	-	252	WP_105879157.1	prevent-host-death protein	-
F9W95_RS07950 (F9W95_07985)	1785131..1785601	+	471	WP_103861352.1	hypothetical protein	-
F9W95_RS07955 (F9W95_07990)	1785601..1785930	+	330	WP_223193302.1	DUF1493 family protein	-
F9W95_RS07965 (F9W95_08000)	1786603..1787085	-	483	WP_010282425.1	SsrA-binding protein SmpB	-
F9W95_RS07970 (F9W95_08005)	1787241..1787687	+	447	WP_010282427.1	type II toxin-antitoxin system RatA family toxin	-
F9W95_RS07975 (F9W95_08010)	1787668..1787958	+	291	WP_039470935.1	RnfH family protein	-
F9W95_RS07980 (F9W95_08015)	1788197..1788532	-	336	WP_011092444.1	outer membrane protein assembly factor BamE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11066.06 Da
• Isoelectric Point: 10.1716

>T141209 WP_233962148.1 NZ_CP045097:c1784096-1783812 [Pectobacterium carotovorum]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQHPHVPANRLHGMADCYKIKLRSAGYRLVYQMLEHEIVVLVLAVGK
RERSEVYKTAKDRL

Nucleotide

• Length: 285 bp

>T141209 NZ_CP059889:c3963288-3962971 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT141209 WP_005973616.1 NZ_CP045097:c1784337-1784086 [Pectobacterium carotovorum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT141209 NZ_CP059889:c3962978-3962691 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6