Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 1303531..1304062 Replicon chromosome
Accession NZ_CP045097
Organism Pectobacterium carotovorum strain RC5297

Toxin (Protein)


Gene name stbE Uniprot ID A0A249QBN7
Locus tag F9W95_RS05815 Protein ID WP_039493031.1
Coordinates 1303775..1304062 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A3R8PFZ6
Locus tag F9W95_RS05810 Protein ID WP_039470361.1
Coordinates 1303531..1303785 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9W95_RS05790 (F9W95_05825) 1298697..1300691 - 1995 WP_240004616.1 penicillin-binding protein activator -
F9W95_RS05795 (F9W95_05830) 1300753..1301640 + 888 WP_103861634.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
F9W95_RS05805 (F9W95_05840) 1302092..1303285 - 1194 WP_103863058.1 IS4 family transposase -
F9W95_RS05810 (F9W95_05845) 1303531..1303785 + 255 WP_039470361.1 plasmid stabilization protein Antitoxin
F9W95_RS05815 (F9W95_05850) 1303775..1304062 + 288 WP_039493031.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F9W95_RS05820 (F9W95_05855) 1304238..1305023 + 786 WP_103971349.1 4,5-DOPA dioxygenase extradiol -
F9W95_RS05825 (F9W95_05860) 1305210..1306370 - 1161 WP_010297418.1 glutathionylspermidine synthase family protein -
F9W95_RS05830 (F9W95_05865) 1306381..1307055 - 675 WP_103861630.1 DUF1190 family protein -
F9W95_RS05835 (F9W95_05870) 1307321..1308715 - 1395 WP_103861629.1 outer membrane channel protein TolC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1302092..1303285 1193


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.93 Da        Isoelectric Point: 10.7694

>T141205 WP_039493031.1 NZ_CP045097:1303775-1304062 [Pectobacterium carotovorum]
MTYKLKFVPSALKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Download         Length: 288 bp

>T141205 NZ_CP059889:702632-703015 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9192.34 Da        Isoelectric Point: 3.7947

>AT141205 WP_039470361.1 NZ_CP045097:1303531-1303785 [Pectobacterium carotovorum]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
PDDL

Download         Length: 255 bp

>AT141205 NZ_CP059889:702174-702542 [Klebsiella pneumoniae subsp. pneumoniae]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249QBN7

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8PFZ6

References