Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 916069..916859 Replicon chromosome
Accession NZ_CP045097
Organism Pectobacterium carotovorum strain RC5297

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag F9W95_RS04100 Protein ID WP_240004579.1
Coordinates 916335..916859 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag F9W95_RS04095 Protein ID WP_010302402.1
Coordinates 916069..916335 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9W95_RS04070 (F9W95_04080) 911440..911991 + 552 WP_240004578.1 TetR/AcrR family transcriptional regulator -
F9W95_RS04075 (F9W95_04085) 912041..912451 - 411 WP_103862408.1 helix-turn-helix domain-containing protein -
F9W95_RS04080 (F9W95_04090) 912566..913417 + 852 WP_040032822.1 SDR family oxidoreductase -
F9W95_RS04085 (F9W95_04095) 913545..914756 - 1212 WP_180790242.1 acyltransferase -
F9W95_RS04090 (F9W95_04100) 915326..915775 + 450 Protein_794 alpha/beta hydrolase -
F9W95_RS04095 (F9W95_04105) 916069..916335 + 267 WP_010302402.1 helix-turn-helix domain-containing protein Antitoxin
F9W95_RS04100 (F9W95_04110) 916335..916859 + 525 WP_240004579.1 HipA N-terminal domain-containing protein Toxin
F9W95_RS04105 (F9W95_04115) 917042..918064 - 1023 WP_103943258.1 RES family NAD+ phosphorylase -
F9W95_RS04110 (F9W95_04120) 918067..918999 - 933 WP_103943256.1 sce7725 family protein -
F9W95_RS04115 (F9W95_04125) 919006..919893 - 888 WP_146119407.1 sce7726 family protein -
F9W95_RS04120 920266..921057 - 792 Protein_800 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19464.95 Da        Isoelectric Point: 5.8508

>T141203 WP_240004579.1 NZ_CP045097:916335-916859 [Pectobacterium carotovorum]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYEGDEVYNFFDNLLPDNPDIRRRIVARYH
TDSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILAGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLSLDDHRQKKHSL

Download         Length: 525 bp

>T141203 NZ_CP059888:c3574919-3574623 [Flocculibacter collagenilyticus]
ATGGCTGAAATAATATGGACAAGGCCCGCTCTAGACGAACTCAATGAGATTGCTGATTATATAGCTGTTGCTAATTTAGC
TGCCGCCCAAAAACTAGTTCAAACAATTTTCGACAAAACGGAAAGATTGGAAACTCATCCAGAATCGGGGAGAGTTCCTC
CTGAAATACCGACTCTAAATTACAGAGAAATCGTAGTAAGCCCATGCCGGATTTTTTATAAACTCGACGGAAATAGACTT
TTTATATTACACGTGATGCGTCAAGAACAAGATCTGAGGCGTTTTTTACTAATTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9887.16 Da        Isoelectric Point: 9.7281

>AT141203 WP_010302402.1 NZ_CP045097:916069-916335 [Pectobacterium carotovorum]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTANNEASV
ASSWKEEW

Download         Length: 267 bp

>AT141203 NZ_CP059888:c3575164-3574907 [Flocculibacter collagenilyticus]
ATGAAAGTTGAATTAGTTACCACATTAAAAAGACAAGCTACTAAAATATTAGCTGATCTTCACTCTACTAAAGAGCCTGT
ATTAATCACTGAACATGGAAAGCCGTCAGCCTATCTAGTTGATGTTGAGGATTATGAAATGATGCAAAGACGCATGGCCA
TATTGGAAGGCATCGCTAGAGGGGAACAGGCGATTAGAAATGATCAGGTAGTGACAAATGAACAAGCCAAAGAGCAAATG
AATAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References