Detailed information of TA system TA141202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 759699..760234
• Replicon: chromosome
• Accession: NZ_CP045097
• Organism: Pectobacterium carotovorum strain RC5297

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9W95_RS03370
• Protein ID: WP_119159036.1
• Coordinates: 759947..760234 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A221TFM4
• Locus tag: F9W95_RS03365
• Protein ID: WP_039533012.1
• Coordinates: 759699..759950 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9W95_RS03335 (F9W95_03355)	755132..755458	+	327	WP_103943145.1	helix-turn-helix domain-containing protein	-
F9W95_RS03340 (F9W95_03360)	755443..755757	+	315	WP_240004567.1	HipA N-terminal domain-containing protein	-
F9W95_RS03345 (F9W95_03365)	755754..756794	+	1041	WP_125232112.1	HipA domain-containing protein	-
F9W95_RS03350 (F9W95_03370)	756855..757478	-	624	WP_233976906.1	LysE family translocator	-
F9W95_RS03355 (F9W95_03375)	757746..758501	+	756	WP_205538192.1	thiol:disulfide interchange protein DsbG	-
F9W95_RS03360 (F9W95_03380)	758536..759441	-	906	WP_103158323.1	siderophore-interacting protein	-
F9W95_RS03365 (F9W95_03385)	759699..759950	+	252	WP_039533012.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F9W95_RS03370 (F9W95_03390)	759947..760234	+	288	WP_119159036.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9W95_RS03375 (F9W95_03395)	760389..763172	+	2784	WP_205538194.1	AAA domain-containing protein	-
F9W95_RS03380 (F9W95_03400)	763316..764668	-	1353	WP_180790314.1	glutathione-disulfide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11028.13 Da
• Isoelectric Point: 10.3527

>T141202 WP_119159036.1 NZ_CP045097:759947-760234 [Pectobacterium carotovorum]
MSYSVKFREDALKEWLKLDKAIQQQFAKKLKKCCENPHIPAAKLRGMKDCYKIKLRASGFRLVYEVIDDILVIAVVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T141202 NZ_CP059855:c1124404-1124054 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9131.50 Da
• Isoelectric Point: 4.0637

>AT141202 WP_039533012.1 NZ_CP045097:759699-759950 [Pectobacterium carotovorum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELIKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT141202 NZ_CP059855:c1124691-1124410 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A221TFM4