Detailed information of TA system TA141199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 7001458..7001983
• Replicon: chromosome
• Accession: NZ_CP045096
• Organism: Streptomyces phaeolivaceus strain GY16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9278_RS32495
• Protein ID: WP_152171477.1
• Coordinates: 7001458..7001721 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F9278_RS32500
• Protein ID: WP_152171478.1
• Coordinates: 7001714..7001983 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9278_RS32475	6997319..6998329	+	1011	WP_152171473.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
F9278_RS32480	6998477..6999223	+	747	WP_152171474.1	ROK family protein	-
F9278_RS32485	6999330..6999887	-	558	WP_152171475.1	hypothetical protein	-
F9278_RS32490	7000236..7001324	+	1089	WP_152171476.1	redox-regulated ATPase YchF	-
F9278_RS32495	7001458..7001721	-	264	WP_152171477.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9278_RS32500	7001714..7001983	-	270	WP_152171478.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F9278_RS32505	7002311..7002571	-	261	WP_152171479.1	hypothetical protein	-
F9278_RS32510	7002647..7003639	-	993	WP_193241729.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-59)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10072.49 Da
• Isoelectric Point: 8.5042

>T141199 WP_152171477.1 NZ_CP045096:c7001721-7001458 [Streptomyces phaeolivaceus]
VSEYRTVFRPEAQSELRKIPRDMALRVLAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T141199 NZ_CP059853:3567210-3567461 [Glutamicibacter nicotianae]
ATGTCCATCAGTGCAAGCGAAGCCCGCAAGACGCTCTTTCCATTGATTGAACAAGTCAACGATGATCGCCAAGCTGTCGA
AATCGTGTCACGCAAGGGAAATGCTGTTCTCATGGCAGCAGATGAATACGCAGCATGGCAAGAGACCGCGTACCTCTTCC
GCTCGCCAGCCAATGCCCGGCGGCTCTTGGATGCCTACGAACGTGCACGGTCAGGAATAACAGAGACCCACGAACTCGAC
TGGGACGAATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10279.70 Da
• Isoelectric Point: 4.6265

>AT141199 WP_152171478.1 NZ_CP045096:c7001983-7001714 [Streptomyces phaeolivaceus]
MTQPLPVESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMASQAPGIPIEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT141199 NZ_CP059853:3567462-3567716 [Glutamicibacter nicotianae]
GTGCGGCTCGTCTGGGATCGGGCAGGATGGGACGACTACGTCCACTGGCAAACGGCCGACCGGCGCGTACTCAAGAGAGT
CAACACCTTGATCGAAGCATGCCTTCCGGATCCCTTCCAAGGGATTGGAAAGCCCGAACAGCTGAAATACGGGGCCTCCG
GCTCATGGTCCCGTCGGATTACCGACGAACACCGACTGGTCTACATCGTGATCGAAGAAGACTTGATCATCCTTCAAGCC
CGATACCACTATTGA