Detailed information of TA system TA141198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 5620052..5620580
• Replicon: chromosome
• Accession: NZ_CP045096
• Organism: Streptomyces phaeolivaceus strain GY16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9278_RS26475
• Protein ID: WP_103544660.1
• Coordinates: 5620052..5620312 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: F9278_RS26480
• Protein ID: WP_103544659.1
• Coordinates: 5620323..5620580 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9278_RS46340	5615429..5615842	-	414	WP_193241643.1	TIGR03618 family F420-dependent PPOX class oxidoreductase	-
F9278_RS26460	5615972..5618608	+	2637	WP_152170539.1	ATP-dependent chaperone ClpB	-
F9278_RS26465	5618877..5619455	+	579	WP_152170540.1	YbjN domain-containing protein	-
F9278_RS26470	5619540..5619974	-	435	Protein_5050	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
F9278_RS26475	5620052..5620312	-	261	WP_103544660.1	Txe/YoeB family addiction module toxin	Toxin
F9278_RS26480	5620323..5620580	-	258	WP_103544659.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
F9278_RS26485	5620722..5621966	-	1245	WP_152170541.1	pyridoxal phosphate-dependent aminotransferase	-
F9278_RS26495	5622480..5622689	+	210	WP_152170543.1	hypothetical protein	-
F9278_RS26500	5622887..5623294	+	408	WP_152170544.1	hypothetical protein	-
F9278_RS26505	5623789..5624310	+	522	WP_152170545.1	DUF2617 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10339.75 Da
• Isoelectric Point: 9.4248

>T141198 WP_103544660.1 NZ_CP045096:c5620312-5620052 [Streptomyces phaeolivaceus]
MKITFSSRAWEDYLWWQLQDRKILKRINTLIADITRNGNEGIGKPEPLKHGFQGYWSRRINDEHRLIYKATEDGVLIAQC
RYHYES

Nucleotide

• Length: 261 bp

>T141198 NZ_CP059851:c3236028-3235756 [Sandaracinobacter sp. M6]
ATGGCCTGGCGGATTGAGTTCGCCGCCAGCGCCGAAAAGCAGCTCCGCAAGCTCGACCCGCAGATCGCGCGCCGCATCCT
GACCTTCCTGCGCGACCGTGTGGCAGCGCTCGACGATCCGCGCAGCATCGGCGAGGCACTGCGCGGGCGTGAATGGGGCG
ACTTCTGGAAATATCGCGTGGGCGACTGGCGGATCATCGCCGACATTGAAGATGAGGTGGTGCTGATCACGGTGGTAAGG
TTGGGTAACCGGCGGGAGGTTTACCGGCGGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9443.48 Da
• Isoelectric Point: 4.3246

>AT141198 WP_103544659.1 NZ_CP045096:c5620580-5620323 [Streptomyces phaeolivaceus]
VKTMTYSESRARYAEVLNSVTDDREEVVITRAGHEPVVIVSLEDYESLKETAYLLRSPANARRLLASIDELESGGGTVRE
LATDE

Nucleotide

• Length: 258 bp

>AT141198 NZ_CP059851:c3236233-3236012 [Sandaracinobacter sp. M6]
ATGTCGCTTCGCCTTCCCGCACCCATCGAGGATCGGCTCTCGGCGCTGGCGGCGCTGACCGGGCGATCAAAGACGTTCTA
CGCGACCGAGGCGATCGTGGAGCATATCGACGATCTGGAGGACGCGCATCTGTCCGCCGCGGTGCGCGCACGGGTGCGCG
CCGGTGCGGAGGGGCGCGTGGCGCTGAGCGAACTGCTGGAAGACTATGGCCTGGCGGATTGA