Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 175833..176428 Replicon plasmid pWSGX1
Accession NZ_CP045089
Organism Burkholderia glumae strain GX

Toxin (Protein)


Gene name chpB Uniprot ID C5AN78
Locus tag GAS19_RS29295 Protein ID WP_012734107.1
Coordinates 176078..176428 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID C5AN79
Locus tag GAS19_RS29290 Protein ID WP_012734108.1
Coordinates 175833..176084 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAS19_RS29255 172149..172385 + 237 WP_017924531.1 AbrB family transcriptional regulator -
GAS19_RS29260 172385..172786 + 402 WP_012735347.1 type II toxin-antitoxin system VapC family toxin -
GAS19_RS30745 173035..173364 + 330 WP_155297075.1 hypothetical protein -
GAS19_RS29270 173382..173612 + 231 WP_153479186.1 hypothetical protein -
GAS19_RS29275 173645..174373 - 729 WP_012735342.1 IS6 family transposase -
GAS19_RS29280 174416..175060 + 645 Protein_162 site-specific integrase -
GAS19_RS29285 175145..175570 + 426 WP_012734109.1 hypothetical protein -
GAS19_RS29290 175833..176084 + 252 WP_012734108.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GAS19_RS29295 176078..176428 + 351 WP_012734107.1 type II toxin-antitoxin system ChpB family toxin Toxin
GAS19_RS29300 176487..176681 + 195 WP_124837685.1 hypothetical protein -
GAS19_RS30750 176831..177052 + 222 WP_017433768.1 hypothetical protein -
GAS19_RS29305 177275..177739 + 465 WP_012734106.1 Lrp/AsnC family transcriptional regulator -
GAS19_RS29310 178041..180428 + 2388 WP_051071184.1 TonB-dependent receptor -
GAS19_RS29315 180418..181206 + 789 WP_012734104.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..201571 201571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.37 Da        Isoelectric Point: 8.8909

>T141196 WP_012734107.1 NZ_CP045089:176078-176428 [Burkholderia glumae]
MVKRVKFERGDIVRVSLSPTVGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEGRGARKIERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T141196 NZ_CP059851:3170418-3170621 [Sandaracinobacter sp. M6]
ATGATGCGCACTGTGAGAAGTTCCGACCTGATCGCTGAGTTATGTGCGGAAGGTTGGATTTTGGATCGGGTGCGGGGCTC
GCACCATGTGTTCCGTCATCCGACGCGAGCGGGCATCACGGTTGTGCCCCATCCGAAGAAAGATCTGGGCGTCGGGCTTG
TGGCCGCCATCCGACGCCAGGCCGGCATGAGGAAGGAGAGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8940.31 Da        Isoelectric Point: 6.2420

>AT141196 WP_012734108.1 NZ_CP045089:175833-176084 [Burkholderia glumae]
MELKIQKWGNSAAVRLPSVLLEQINASVGGSLNADVRPDGVLLTPARRKYALDDLVAQCDTKAPVPADMAAWGEIKPVGR
EAW

Download         Length: 252 bp

>AT141196 NZ_CP059851:3170621-3171019 [Sandaracinobacter sp. M6]
ATGCGCTATCCGATCGCGATCGAGCCGGCAACGGCCGGCACTGCCTATGGGGTGGTCATTCCGGACCTGCCGGGGGCTTT
TTCAGCGGGAGACACGCTTGATGAGGCCATGGCAGGCGCGGAGGAGGCCGCGGCTGCCTGGATCGACGCGACCCTGGATG
CCGGGGGTGCCATTCCTGAGCCTTCCAGCCTGGAAGCCGTTCGCGATGATCCCGCCTTTGCGGGATGGAGTTTCGGCGTG
ATCACGCTCGATCCGGCGCTGCTTGACGATGCCATCGAACGGATCAACGTCACGCTGCCACGCCGGGTGTTGCGGCGTCT
GGACAGCATGGCCCGGTCGGCCGGCGCGAGCCGGTCCGGGTATATCGCGCGCATGACGCTGTCCGACCGGACGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246MF70

Antitoxin

Source ID Structure
AlphaFold DB A0A246MFN5

References