Detailed information of TA system TA141194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 163581..164118
• Replicon: plasmid pWSGX1
• Accession: NZ_CP045089
• Organism: Burkholderia glumae strain GX

Toxin (Protein)

• Gene name: parE
• Uniprot ID: C5AN85
• Locus tag: GAS19_RS29195
• Protein ID: WP_012734112.1
• Coordinates: 163816..164118 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: C5AN86
• Locus tag: GAS19_RS29190
• Protein ID: WP_012734113.1
• Coordinates: 163581..163826 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAS19_RS29170	158670..159527	-	858	WP_012734037.1	replication initiator protein A	-
GAS19_RS29175	160282..161247	-	966	WP_012734036.1	ParB/RepB/Spo0J family partition protein	-
GAS19_RS29180	161247..161918	-	672	WP_012734035.1	AAA family ATPase	-
GAS19_RS29185	163234..163428	+	195	WP_043308437.1	hypothetical protein	-
GAS19_RS29190	163581..163826	+	246	WP_012734113.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GAS19_RS29195	163816..164118	+	303	WP_012734112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GAS19_RS29200	164278..164520	+	243	WP_043308436.1	hypothetical protein	-
GAS19_RS29205	164728..165183	+	456	WP_012734111.1	hypothetical protein	-
GAS19_RS29210	165187..165468	+	282	WP_043308454.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GAS19_RS29215	165652..165969	+	318	WP_148271069.1	hypothetical protein	-
GAS19_RS29220	166226..166510	+	285	WP_017924445.1	hypothetical protein	-
GAS19_RS29225	166523..166762	+	240	WP_017924444.1	hypothetical protein	-
GAS19_RS29230	166759..167004	+	246	WP_153479180.1	hypothetical protein	-
GAS19_RS29235	167105..167446	+	342	WP_039204389.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..201571	201571

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-92)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11548.11 Da
• Isoelectric Point: 6.7171

>T141194 WP_012734112.1 NZ_CP045089:163816-164118 [Burkholderia glumae]
MRGKARVVRLTPLAEADLEDIWAYIFEQWSLAQAEQYVGEIVAAFNRLARGEWVGAVRGEPYRRYLVGFHAVFYRETTDA
LDVACVRHQRMDVGSHLSQY

Nucleotide

• Length: 303 bp

>T141194 NZ_CP059851:c3105910-3105629 [Sandaracinobacter sp. M6]
ATGGCGATCGAAACCAAGCCGTGGGATGCCGCCGAGGTGCTGAACACGCCGGCGGACATTGCCGCCTATCTGGATGCCTA
TCTGGAAGATGGCACGCCCGAGGAGCTGCTGCGGGCGGTGAAGGCGATTGCCCGGTCGCGTGGCATGTCCGAGCTGGCGC
GGCAGAGCGGCATCAGCCGGGAGGCGCTGTATCGCGCGTTTGGCGACAAGGGGAATCCCACGTTGGATACGCTGCTGCGG
GTTATGAAGGCGCTGGGGGTTAGGCTGGCCATTGCGGCGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8645.69 Da
• Isoelectric Point: 7.2029

>AT141194 WP_012734113.1 NZ_CP045089:163581-163826 [Burkholderia glumae]
MPRNTSISLGDHLTQFVDTQVASGRYGSASDVVRAGLRLLETQETELKALKEALRASEASGAPAAFDGQAFLDRMRAKHA
G

Nucleotide

• Length: 246 bp

>AT141194 NZ_CP059851:c3106203-3105913 [Sandaracinobacter sp. M6]
ATGTTTGAGGTCAGGCGGACGGGCGCATTCATCGACTGGCTGACTGGGTTGAAGGATGTGCAGGGGCGGGCGCGGATTGC
AAAACGCCTTGACCGGCTGGTGGACGGCAATTTCGGGGATGCCAAGTCCGTTGGCGGCGGCGTGAGCGAACTGCGGTTTA
CGTTCGGCCCGGGGTATCGGGTTTATTTCACGGTGCGCGGTCAGGTTGTTGTCATCCTGCTGTGTGGTGGCGACAAGCAG
AGCCAGGTGCGTGACATCGACCGGGCGATCTTGATGGCGAAGGAGGTTTGA

Structures

Toxin

• AlphaFold DB: C5AN85

Antitoxin

• AlphaFold DB: C5AN86