Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2133498..2134273 Replicon chromosome
Accession NZ_CP045088
Organism Burkholderia glumae strain GX

Toxin (Protein)


Gene name TacT2 Uniprot ID C5AIF4
Locus tag GAS19_RS25745 Protein ID WP_015877380.1
Coordinates 2133498..2133995 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID C5AIF5
Locus tag GAS19_RS25750 Protein ID WP_015877381.1
Coordinates 2133992..2134273 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAS19_RS25715 2128952..2130301 + 1350 WP_015877376.1 allantoin permease -
GAS19_RS25725 2130548..2131102 - 555 Protein_1716 IS3 family transposase -
GAS19_RS25730 2131222..2131506 - 285 WP_153478924.1 hypothetical protein -
GAS19_RS25735 2131907..2132506 - 600 Protein_1718 RHS domain-containing protein -
GAS19_RS25740 2132920..2133417 - 498 WP_015877379.1 ProQ activator of osmoprotectant transporter prop -
GAS19_RS25745 2133498..2133995 - 498 WP_015877380.1 GNAT family N-acetyltransferase Toxin
GAS19_RS25750 2133992..2134273 - 282 WP_015877381.1 DUF1778 domain-containing protein Antitoxin
GAS19_RS25755 2134270..2134647 - 378 WP_173941242.1 hypothetical protein -
GAS19_RS25760 2134730..2135092 - 363 WP_017432434.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2130530..2147807 17277
- flank IS/Tn - - 2130530..2131072 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-91)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17544.11 Da        Isoelectric Point: 9.6894

>T141192 WP_015877380.1 NZ_CP045088:c2133995-2133498 [Burkholderia glumae]
VTGWRAPEPLSDAHGLDDFDSGVASLDTWLKRRALANQRSGASRTFVATRDGRVGAYYALASGAVTLEVAPGRFRRNMPD
PIPVVVLGRLAVDRAHQGIGVGRALVRDAGLRVLHAAAAIGIRGLIVHALSDSAKAFYERVGFEASPLDPMLLLITLADL
EHALS

Download         Length: 498 bp

>T141192 NZ_CP059851:3098901-3099242 [Sandaracinobacter sp. M6]
ATGTATATCATTGAGCGCACCGTCGTCTTTGATGGGTGGCTCGATGGCCTGAAAGACCGGACGGCGCAAAAGCGGGTTGC
CATGCGCCTGACGCGCATTGAATCGGGGCTTCTGGGCGACTGGAAAACACTCGGAGACGGCATCAGCGAACTGCGAATCG
ACCATGGCCCCGGATACCGGATTTACTTCACCCGGCGGGATCAACGGATCATCATCCTGTTGTGTGGCAGCGACAAGGGA
GATCAGGATCGGGCGATCAGACAGGCAAGGCAAATGGCCAAAGACCTTGATATCCCTCTGATGACATCTCCCCGTCCCCA
ACGACCTGGAACAACGGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10256.52 Da        Isoelectric Point: 5.0477

>AT141192 WP_015877381.1 NZ_CP045088:c2134273-2133992 [Burkholderia glumae]
MTSTTPRDTLNLRIRPDDRSLIDRAAAAAHKTRTDFVLDAARAAAEQTLLDQVVLSAEPQAYAAFLARLDEPVQPNEALR
QTMQTRAPWDPAA

Download         Length: 282 bp

>AT141192 NZ_CP059851:3099239-3099547 [Sandaracinobacter sp. M6]
GTGACCATGACCCAGCTTGCGACCACCCCATTCGACGCCGCCAAATATATCACCGAGCCCGCGGATGTGGTCGACTTCCT
CAACGACGCGTTCGACAGCGGCCATGCCCCCTACATCGCCAAAGTGCTGGGCATCGTCGCGCGCAGCGAAGGCATGTCGA
AAATCGCCGACAAGACCGGCGTCAACCGTCAGGCCCTCTACACCGCGCTCAGCGAGCAGGGCAATCCGACGCTGGAAACG
CTCCTCAAGGTCCTGTCCGCCCTCGGCATGAAACTGAAATGCGAACCCGACCTGGCGAAAGCAGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9HNC8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9HNC9

References