Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1697703..1698227 Replicon chromosome
Accession NZ_CP045086
Organism Staphylococcus pseudintermedius strain KCTC 43136

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag GAN21_RS07985 Protein ID WP_014613379.1
Coordinates 1697874..1698227 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag GAN21_RS07980 Protein ID WP_014613378.1
Coordinates 1697703..1697873 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAN21_RS07955 1693592..1694065 + 474 WP_014613373.1 PH domain-containing protein -
GAN21_RS07960 1694058..1695587 + 1530 WP_014613374.1 PH domain-containing protein -
GAN21_RS07965 1695571..1696089 + 519 WP_014613375.1 PH domain-containing protein -
GAN21_RS07970 1696086..1696436 + 351 WP_014613376.1 holo-ACP synthase -
GAN21_RS07975 1696470..1697618 + 1149 WP_140239190.1 alanine racemase -
GAN21_RS07980 1697703..1697873 + 171 WP_014613378.1 hypothetical protein Antitoxin
GAN21_RS07985 1697874..1698227 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GAN21_RS07990 1698285..1699289 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
GAN21_RS07995 1699368..1699694 + 327 WP_014613381.1 anti-sigma factor antagonist -
GAN21_RS08000 1699694..1700173 + 480 WP_031253870.1 anti-sigma B factor RsbW -
GAN21_RS08005 1700148..1700918 + 771 WP_152162928.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T141191 WP_014613379.1 NZ_CP045086:1697874-1698227 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T141191 NZ_CP059851:2989736-2990026 [Sandaracinobacter sp. M6]
ATGAGCTCGGCGCTCTACAGCAACAGGGCGGTCGACGACCTTCGCACCATCGAAACCTACACCGCAACGCAATGGGGTGA
TGCCCAAGCCGACCGATATGTTCGGGCCATCATGACGGCAGTGGACAGGCTGGCTGAAAATCCTGCGCTTGGACGGGCAG
TTGCCGTCAACTTCGGACAATATCGACGGATATCATCGGGCTCCCATGTTATCTATGTCGTTGTGCAGGATGGCCAGACG
ACAGTCGTTCGCATTCTGCACCAGCGCATGGAACCTGGGCTGCATCTCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT141191 WP_014613378.1 NZ_CP045086:1697703-1697873 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT141191 NZ_CP059851:2989479-2989739 [Sandaracinobacter sp. M6]
ATGGTTGCCATCGCTCCTGCGCGCACTCTCACCATGAAGCTTGGGCCCTATTTCGACAGGCTGATCGAAGGCCAGATCGC
CAGCGGGAGATATGGCAGCGTTGATGATGTCATTCGCGAGGCGCTCACCCGACTGCAGGATCATGAAACCCGCGTGGAGG
CACTAGGCGAGGCACTGCGAGAGGGGGAAGAAAGCGGCCTGCATGGCCCCCTTGATGCCAATGCCTTTCTGCAGGAATGT
CGTGCCGCTCGAAGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References