Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1682788..1683309 Replicon chromosome
Accession NZ_CP045086
Organism Staphylococcus pseudintermedius strain KCTC 43136

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag GAN21_RS07915 Protein ID WP_014613364.1
Coordinates 1683088..1683309 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag GAN21_RS07910 Protein ID WP_014613363.1
Coordinates 1682788..1683075 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAN21_RS07885 1678049..1678852 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
GAN21_RS07890 1678842..1679480 + 639 WP_014613359.1 thiamine phosphate synthase -
GAN21_RS07895 1679569..1680435 + 867 WP_014613360.1 membrane protein insertase YidC -
GAN21_RS07900 1680489..1681145 - 657 WP_014613361.1 HD domain-containing protein -
GAN21_RS07905 1681166..1682656 - 1491 WP_014613362.1 cardiolipin synthase -
GAN21_RS07910 1682788..1683075 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
GAN21_RS07915 1683088..1683309 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
GAN21_RS07920 1683313..1683519 + 207 WP_014613365.1 cation transporter -
GAN21_RS07925 1683620..1685800 + 2181 WP_115807195.1 heavy metal translocating P-type ATPase -
GAN21_RS12505 1685886..1686032 + 147 WP_014613367.1 hypothetical protein -
GAN21_RS07930 1687000..1687727 + 728 Protein_1538 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T141190 WP_014613364.1 NZ_CP045086:1683088-1683309 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T141190 NZ_CP059851:c2935716-2935462 [Sandaracinobacter sp. M6]
ATGCGAGCAATGCACTATTCCGATACGCGGGCGAACTTGAAAACCGTGATGGACCGGGTGGTCGATGACCATGAGCCTGT
CATCGTCACGCGCCGTAACGGGGAGCCGGTGGTGATCGTATCGCTGTCGGACTGGAACTCAATGGACGAGACTGCCTATC
TCTTGTCCACGCCGGCCAATGCGGCGGCGTTGCGCGAGGCGGTGGCCGGCTTGAACGCCGGGCTGGGTGTGGAACGCGAA
CTCATCAATCCGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT141190 WP_014613363.1 NZ_CP045086:1682788-1683075 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT141190 NZ_CP059851:c2935465-2935199 [Sandaracinobacter sp. M6]
GTGATCATCGTCTTCTTCCCGACCGCCTGGACAGCCTATTGTCACTGGCAGGCAACGGACAGGCAGACCCTGGAACGTTT
GAACGCCCTGATCGAGGAATGTTGTCGTCACCCCTTCACCGGAACCGGAAAGCCGGAGCCTTTGAAAAACGAGCTGAAAG
GGTTCTGGTCCCGTCGCATCACACGCGAAGACCGGCTGGTCTATCGTGTAGCCGGGCAGGGCAAGGAGCAACGGCTGGAA
ATCGCGCAATGCCGTTTTCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References