Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 241300..241821 Replicon chromosome
Accession NZ_CP045084
Organism Staphylococcus pseudintermedius strain KCTC 43134

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag GAN19_RS01280 Protein ID WP_014613364.1
Coordinates 241300..241521 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag GAN19_RS01285 Protein ID WP_014613363.1
Coordinates 241534..241821 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAN19_RS01265 236882..237609 - 728 Protein_211 peptidase -
GAN19_RS01270 238809..240989 - 2181 WP_115807195.1 heavy metal translocating P-type ATPase -
GAN19_RS01275 241090..241296 - 207 WP_014613365.1 cation transporter -
GAN19_RS01280 241300..241521 - 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
GAN19_RS01285 241534..241821 - 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
GAN19_RS01290 241953..243443 + 1491 WP_014613362.1 cardiolipin synthase -
GAN19_RS01295 243464..244120 + 657 WP_014613361.1 HD domain-containing protein -
GAN19_RS01300 244174..245040 - 867 WP_014613360.1 membrane protein insertase YidC -
GAN19_RS01305 245129..245767 - 639 WP_014613359.1 thiamine phosphate synthase -
GAN19_RS01310 245757..246560 - 804 WP_014613358.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T141184 WP_014613364.1 NZ_CP045084:c241521-241300 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T141184 NZ_CP059851:1174679-1175152 [Sandaracinobacter sp. M6]
GTGCCGGCGTGGAGCTGGGCGCCCTTGTCGGGCGAGGGCGCGGCGCGGTTCGGCGGGCGGTGGAATGCGCGCGGGCAGGC
GGCGATCTATGGCGCGCTGGAGCTGGCGACGGCCTGGTCGGAATATAATCAGGGGTTGTCGCAGCATCCGGGCCTGGTGG
CGCGGCTGCATGTCAGGGGGGCGCGGCTGGCCGATGTTCGCGACGCGGATCTGCGGGTGGCGCATGGCGTGCCCGATGAT
CTGGGGGGCGACAGCTGGCGCGCGGCGATGACGGCGGCAGGCGTGGCACCCACGCAGGCGGCCGCGCTGCGGATGATGGC
GGCGGGTTATGACGGGCTGCTGGCGCCGAGCTTCATGGCGCCAGGCGGAAAGACGGCGGTGTTGTGGCGCTGGAACCGGG
ATGGTGCGCCCGGGGTGATGGTGGAAGACCCGGAAGGGAGGCTGCCGCGGGATGGGGCGAGCTGGTCGGGTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT141184 WP_014613363.1 NZ_CP045084:c241821-241534 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT141184 NZ_CP059851:1174479-1174643 [Sandaracinobacter sp. M6]
ATGGCCGCCGACATGAGCGGCTCGCCCGAGCGGGCCGCGCTGTGGTTCAAGCATCAGCCGCTGCCGGGCTGGGCCGGCAA
GACCGCGCGCGACCTGATCGCCGAAGGTCGTGCACAGGACGTCATGGACTATCTGGAAGCGGTGCGCGCCGGGGTTCACG
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References