141183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 226382..226906 Replicon chromosome
Accession NZ_CP045084
Organism Staphylococcus pseudintermedius strain KCTC 43134

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag GAN19_RS01210 Protein ID WP_014613379.1
Coordinates 226382..226735 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag GAN19_RS01215 Protein ID WP_014613378.1
Coordinates 226736..226906 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAN19_RS01190 223691..224461 - 771 WP_152162928.1 RNA polymerase sigma factor SigB -
GAN19_RS01195 224436..224915 - 480 WP_031253870.1 anti-sigma B factor RsbW -
GAN19_RS01200 224915..225241 - 327 WP_014613381.1 anti-sigma factor antagonist -
GAN19_RS01205 225320..226324 - 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
GAN19_RS01210 226382..226735 - 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GAN19_RS01215 226736..226906 - 171 WP_014613378.1 hypothetical protein Antitoxin
GAN19_RS01220 226991..228139 - 1149 WP_140239190.1 alanine racemase -
GAN19_RS01225 228173..228523 - 351 WP_014613376.1 holo-ACP synthase -
GAN19_RS01230 228520..229038 - 519 WP_014613375.1 PH domain-containing protein -
GAN19_RS01235 229022..230551 - 1530 WP_014613374.1 PH domain-containing protein -
GAN19_RS01240 230544..231017 - 474 WP_014613373.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T141183 WP_014613379.1 NZ_CP045084:c226735-226382 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T141183 NZ_CP059851:c679521-679153 [Sandaracinobacter sp. M6]
TTGATCCTGGCCGACACGAATATCTGGCTCGTTCATTTTCGTCAGCCGGATGCAAAGCTGACCGAACTTGTCAGCAATCG
TCAACTTCACGTCCATCCGATGGTGCTGGGTGAAATCGCCGTCGGGCCGATCATAGGACGCGATGACGTGCTGACCATGC
TCGATGAACTCCCGCGATGCGAAACCGCATCGCATGAAGAGGTGATGCAATTTATCGAATCCGTCCCGCTCCATTCCCGC
AAACTCAGCTACATCGATGTGCATCTGCTTGCCGCAACGATGCTCACCGCCGGCTGTCGCCTCTGGACGCGCGACCGGCG
GCTCCTCGCCGCAGCCGGTCTGCTGAAACTCGGCGCCGACTTGCCATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT141183 WP_014613378.1 NZ_CP045084:c226906-226736 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT141183 NZ_CP059851:c679742-679518 [Sandaracinobacter sp. M6]
ATGCGTACAACTGTCACCCTGGATGATCGGCTGATCGAACGGGCCGCGGTCTATTCCGGTCTCAAGGAAAAATCGGCGGT
CATCAATGAAGCCTTGCGGTCCTATGTGGCGTGGCAGGCCGGACTCCGGCTGGCAGCGCTGGGCGGAACGATGCCCGACC
TGGAAATCACCCCGCGAAAGCGACCATGGGACGAGTTCGGCGCTGACAGCGAGCCTTTTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References