Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1160519..1161180 Replicon chromosome
Accession NZ_CP045073
Organism Paracoccus kondratievae strain BJQ0001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F8A10_RS17080 Protein ID WP_036747427.1
Coordinates 1160791..1161180 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5P8JJZ9
Locus tag F8A10_RS17075 Protein ID WP_011746827.1
Coordinates 1160519..1160782 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8A10_RS17050 1155557..1156171 + 615 WP_152367985.1 XRE family transcriptional regulator -
F8A10_RS17055 1156357..1157523 + 1167 WP_011746823.1 alpha/beta hydrolase -
F8A10_RS17060 1157520..1158293 + 774 WP_011746824.1 SDR family oxidoreductase -
F8A10_RS17065 1158429..1159667 + 1239 WP_011746825.1 MFS transporter -
F8A10_RS17070 1159862..1160197 - 336 WP_128492979.1 hypothetical protein -
F8A10_RS17075 1160519..1160782 + 264 WP_011746827.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F8A10_RS17080 1160791..1161180 + 390 WP_036747427.1 type II toxin-antitoxin system VapC family toxin Toxin
F8A10_RS17090 1162008..1162346 + 339 WP_011746829.1 type II toxin-antitoxin system RelE/ParE family toxin -
F8A10_RS17095 1162343..1162627 + 285 WP_193668244.1 helix-turn-helix domain-containing protein -
F8A10_RS17100 1162737..1163120 + 384 WP_152367987.1 transcriptional regulator -
F8A10_RS17105 1164033..1165754 + 1722 WP_152367988.1 hypothetical protein -
F8A10_RS17110 1165751..1166104 + 354 WP_152367989.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(16-53)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13599.59 Da        Isoelectric Point: 5.1700

>T141182 WP_036747427.1 NZ_CP045073:1160791-1161180 [Paracoccus kondratievae]
MLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILESVQVLALDVPADAEYGGIR
AELEAAGKPIGPNDLLIAAHAYAAGAILVTDNTGEFSRVRGLRVENWIR

Download         Length: 390 bp

>T141182 NZ_CP059851:350413-351288 [Sandaracinobacter sp. M6]
ATGGCTAAGACACCGACCGACATGGCCAAATCCGTTAAGGATCGGCTGCTGAACATCGCCCGCCAGGAAGGCCGGGTGTT
CGACGTTCTGTTGGTGCGGTTCGCGCTGGAACGTCTGCTCTATCGGCTGTCGATTTCGGAGCATCGGGACCGTTTCGTCC
TGAAGGGTGGAATGCTGGTAACGGTCTGGGTCGAAGACGACAATCGGGTCACCCGAGATGCGGACTTCCTGGGCCATGGC
GATCCCAACCCCGAACGCCTAACCGCCGACTTCCGGGAGATCATGGCGATCGAGAGCGAGGACGGCCTCGTTTTCGACCT
CGACTCCCTGGCTGCGACAGCAATCCGCGAGGAGATGGAATATGGCGGCACTCGCCTTAAGACCGCGGCTTATCTCGAAA
AGACGCGCATCCCTGTGACGATCGATATCGGCTTTGGCGACGCGATGGCCGATGCTACCCAGCGACTGGACTATCCAACC
TTGCTGGATCTCCCTGCGCCCAATGTGCGTGCCTATACGCCCGCCACCGTTATCGCCGAGAAATTCCAGGCGATGGTCGC
GCTTGGCGTCCTGAACGGACGGATGAAGGACTACTACGATTTGTGGGCGATCCCGCGCGCGCTCAATATTGCCGCTGAAG
ATCTGGATGCGGCCATCACCGCGACGTTCGAGCGCCGCCAGACGGCGATCCCGACGGAAAGGCCGCCGGGACTTTCGGCC
GAAATGGTCGATGATGAGGTCAAGCAGCGCCAATGGCGTGCCTACGCAGCATCCGTCGAACTTGAGGGCGTCTCTCTGGA
ATCGATCGTCGACACGGTGTGGGGACTGGTCGGACCATCCTGCGCGAGGATCGCGGCAAAGGCAGCGAAGGCATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9842.23 Da        Isoelectric Point: 4.8232

>AT141182 WP_011746827.1 NZ_CP045073:1160519-1160782 [Paracoccus kondratievae]
MPHPQPSSGPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPLRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAKEIDL

Download         Length: 264 bp

>AT141182 NZ_CP059851:349860-350420 [Sandaracinobacter sp. M6]
ATGATGCGCGCACACGAACTGCGTGAAGCTGGGATCAGCGCGCAAACGATCGCGCGTGCCGTCGAGACCGGGGACATCGA
ACGCATATCGCGCGGGGTTTACCAGAGGCGTGGATCCGAGATCGAAGAGAACCAAATCCTCGCCGAGGCCACCATGCGCG
TCCCCAAGGGTGTTATCGCTCTTGTGTCGGCGCTCGCGTTTCACGGCCTGACCGATCAGATGCCGCGGCGCATCTGGATG
GCCATCGGTGCCAGTGACTGGGCTCCGGTGCAGGCCTATCCCCCGATGCGCATGGTGCGGTTTACCGAGCCTTACCTGCG
CCAGGGTGTCGAGAACCATATGATCGCTGGCCTTCAGGTCCCGATCTATTCCGTGCCGAAGACGCTTGCCGACCTTTTCC
GCAATTCGAAGCTGGTTGATCGGTCGGTCGCCGTGGAAGGCCTGCGCGCCACCATCGAACAGCGCAAGGCGACCCCGAGC
GCGATCGCGCAGGGGGCGAAAGACGGCGGCGCTTGGAAGATCATGCAACCCTATCTCGAGGCGCTCACGTCCAATGGCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5P8JJZ9

References