Detailed information of TA system TA141181

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 695917..696587
• Replicon: chromosome
• Accession: NZ_CP045073
• Organism: Paracoccus kondratievae strain BJQ0001

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F8A10_RS14795
• Protein ID: WP_152367721.1
• Coordinates: 696153..696587 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F8A10_RS14790
• Protein ID: WP_095641522.1
• Coordinates: 695917..696156 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8A10_RS14765	691981..692325	-	345	WP_018000081.1	HNH endonuclease	-
F8A10_RS14770	692465..692842	-	378	WP_152367717.1	helix-turn-helix domain-containing protein	-
F8A10_RS14775	692835..693035	-	201	WP_193668321.1	hypothetical protein	-
F8A10_RS14780	693371..695596	-	2226	WP_152367719.1	AAA family ATPase	-
F8A10_RS14785	695593..695793	-	201	WP_152367720.1	hypothetical protein	-
F8A10_RS14790	695917..696156	+	240	WP_095641522.1	Arc family DNA-binding protein	Antitoxin
F8A10_RS14795	696153..696587	+	435	WP_152367721.1	PIN domain-containing protein	Toxin
F8A10_RS14800	696584..697291	-	708	Protein_702	sigma-70 family RNA polymerase sigma factor	-
F8A10_RS14805	697389..697622	-	234	WP_115754683.1	hypothetical protein	-
F8A10_RS14810	697716..699878	-	2163	WP_152367722.1	hypothetical protein	-
F8A10_RS14820	700212..700661	+	450	WP_152367723.1	DUF2924 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	681720..723061	41341

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-129)

Antitoxin

• Arc-like DNA binding domain (5-45)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15417.70 Da
• Isoelectric Point: 5.1875

>T141181 WP_152367721.1 NZ_CP045073:696153-696587 [Paracoccus kondratievae]
MIILDTNVVSETMKPVPEPRVIDWLNRQELSTLHLTTVSLAELRFGMARLEPGRRRDDFELRLERMLTEVFPGRVLGFDA
AAANAFGALVATAGRQGHAVSFADGAIAAIAAASGYPVASRDTAPFAAMGVKVVDPWGLPANEA

Nucleotide

• Length: 435 bp

>T141181 NZ_CP059851:310080-311348 [Sandaracinobacter sp. M6]
ATGACGCGCACCCTCGATATCTGGTGGGACGGGCGCCTGGTAGGCCAGCTGACGCAGGACAAGCACGGTGAACTCGGCTT
CGCCTATGCGCGGGCTTGGCTTGACGATGAGGAGGCGCAGCCCTTGTCCGCCTCGCTGCCAAAGCGGGCGGAGCCGTTCA
CCCGCCGCGAATGCCGCCCGTATTTCAGCGGTCTCCTGCCGGAAGAAAGCCAGCGCGACGCCGCAGCTCAGGCACTCGGC
GTGTCGCGGGCCAATGATTTCGCCCTTCTTGATCGCCTCGGCGGCGATGTGGCGGGCGCGCTCCAGCTTCTGCCGCCCGG
CGAAGTACCAGCCACTCTTGCCCCCGATCAACGGCCAACCCCGCTTGACGATGCAGGGTTGATCCGGGTTCTGGATGCGC
TGCCCGTCCGACCATTGCTGGCTGGCGAGGAAGGCCTGCGTCTCTCTCTCGCTGGCGCGCAATCGAAGGTTCCGGTGGTT
CTGGTGGATGGCGTGGTGGCCTTGCCTGCGCCGGGCCAGCCGACGACGCATATTCTCAAGCCCCCGATATCCCGCTTCGC
GGCCACGACCGAGAACGAGGCGTTTGTGATGCGCCTTGCTGCCGCAATCGGCTTCGATGTCGCGCCGGTAGAAGTCCGCA
TCGTGCAGGATCGAACATTTCTGCTGGTCCAGCGCTATGACCGCGCCACCGGCGACGATGGCTTCGTGCGCCGGATCCAT
CAGGAGGATTTCTGCCAGGCGCTCGGCGTGCCGCCGGAGACCAAGTACGCCAGCGAGGGCGGCCCGACGTTCAAGGATTG
CTTCGCGCTGCTCCGCCGGGTCGTCGCAAGGCCCGCTGTCGATGTGCTGAAGCTCCTCGATGCCGTGATCTTCAATGTGA
TCGCCGGGAACGCCGACGCACATGGCAAGAATTTCTCGATCCTCTACGGCGCCGAAGGCCCACGCCTCGCCCCGCTCTAT
GATCTGCTCGCAACCGTTGCCTATCCCGATCTCTCGCCGAAATTCGCTATGAAGATCGGAAGGCGGGCGACGCTCGCGGA
ACTGGACGCCGATGGCTGGGCAGCGTTTGCGGCGGACGCGGGTGTCGGTCTGCCGCTGGTACGACGACGGATTGCAGAGA
TCAGCAAAGCTGTCCTTGAGAAGGCAACCGCCGTCGGAGCCGAGCTTTCGCGTCCAGGGTTGGACAGAACGGCTATTGCG
CGGTTTGCCGAGATGATCCGCGAGCGCGGCGAGCGCTGCGCTCTTACGGTCGCGGGACCTTCTCAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8662.88 Da
• Isoelectric Point: 7.1682

>AT141181 WP_095641522.1 NZ_CP045073:695917-696156 [Paracoccus kondratievae]
VAQIVVRQIPDEVHRALKAQAAAHGRSAEAELREIIARAVLREGRPRAGDLMRGIWSGAAMDGFSVERDRTPVEPACFE

Nucleotide

• Length: 240 bp

>AT141181 NZ_CP059851:309841-310083 [Sandaracinobacter sp. M6]
ATGGCCAGACGCAACCTCACCACCGCCGAGATCGGCGACATTGTTCGGACAACCCGCAAGGCCGCTGGCCTGCGGCAGGA
CGAGCTTGCCGGCGCAGCTGGCGTCGGCCTGCGCTTCATCGTCGATCTCGAAGCGGGCAAGGCGACCGCGCAGATCGGCA
AGACGCTTCAGGTCCTATCGGCGCTGGGCTGCTCGCTCGATATCACACCGCCGTCCGACCCCAAAGGAGCGCGGAAGGCA
TGA