Detailed information of TA system TA141180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 293888..294417
• Replicon: chromosome
• Accession: NZ_CP045073
• Organism: Paracoccus kondratievae strain BJQ0001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F8A10_RS12805
• Protein ID: WP_152366699.1
• Coordinates: 293888..294175 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: F8A10_RS12810
• Protein ID: WP_152366700.1
• Coordinates: 294172..294417 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8A10_RS12770	289799..290044	-	246	WP_010399197.1	helix-turn-helix domain-containing protein	-
F8A10_RS12775	290154..290477	+	324	WP_152367524.1	zinc ribbon domain-containing protein	-
F8A10_RS12780	290652..291161	+	510	WP_152367525.1	hypothetical protein	-
F8A10_RS12785	291158..291436	+	279	WP_152368144.1	hypothetical protein	-
F8A10_RS12790	291574..291783	+	210	WP_152367526.1	hypothetical protein	-
F8A10_RS12795	292112..293284	+	1173	WP_152367527.1	ATP-binding protein	-
F8A10_RS12800	293506..293799	-	294	WP_152366698.1	hypothetical protein	-
F8A10_RS12805	293888..294175	-	288	WP_152366699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F8A10_RS12810	294172..294417	-	246	WP_152366700.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
F8A10_RS12815	294522..295883	-	1362	WP_152367528.1	plasmid recombination protein	-
F8A10_RS12820	295876..296733	-	858	WP_010396088.1	hypothetical protein	-
F8A10_RS12830	297215..298012	+	798	WP_010396086.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
F8A10_RS12835	298111..298524	+	414	WP_085501863.1	YHS domain-containing protein	-
F8A10_RS12840	298712..299164	+	453	WP_152367529.1	CoA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	273534..296983	23449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10638.11 Da
• Isoelectric Point: 6.4738

>T141180 WP_152366699.1 NZ_CP045073:c294175-293888 [Paracoccus kondratievae]
MKALAFTVAATVDLEAIWDYTEGEWGLAQARRYVQELRDTCHALASGQGRGRPVDVRPGYLKCLSGSHVIFFRDLGDTLE
IVRILHGAQDVERHL

Nucleotide

• Length: 288 bp

>T141180 NZ_CP045073:c294175-293888 [Paracoccus kondratievae]
ATGAAGGCGTTGGCCTTCACCGTCGCGGCAACGGTCGATCTGGAGGCAATCTGGGACTATACGGAGGGCGAATGGGGCCT
CGCGCAAGCCCGGCGCTATGTGCAGGAACTGCGCGACACCTGCCACGCGCTGGCATCTGGGCAAGGGCGCGGCAGGCCGG
TTGACGTTCGGCCTGGCTATCTGAAATGCCTGAGCGGATCGCATGTCATCTTCTTCCGGGATCTGGGCGACACGCTGGAA
ATCGTCCGCATCCTGCACGGTGCACAGGACGTCGAGCGGCATTTGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8810.88 Da
• Isoelectric Point: 7.2038

>AT141180 WP_152366700.1 NZ_CP045073:c294417-294172 [Paracoccus kondratievae]
MSRNTSVSLGDHFVSFIDTQVKGGRYGSASDVVRAGLRLLEEHETKVKALQDALIAGEESGRAEGFDLDRFIARKMAGRN
A

Nucleotide

• Length: 246 bp

>AT141180 NZ_CP045073:c294417-294172 [Paracoccus kondratievae]
ATGTCCCGCAACACTTCGGTTTCGCTCGGCGATCACTTCGTCAGCTTCATCGACACGCAGGTGAAGGGGGGCCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGGCTGCTGGAGGAGCACGAGACCAAGGTAAAGGCCCTTCAGGACGCCC
TGATCGCCGGAGAGGAATCCGGCCGGGCGGAGGGTTTCGACCTCGACCGGTTCATTGCCCGCAAGATGGCCGGTCGCAAC
GCATGA