Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1633984..1634654 Replicon chromosome
Accession NZ_CP045072
Organism Paracoccus kondratievae strain BJQ0001

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P8JDY4
Locus tag F8A10_RS08185 Protein ID WP_011748362.1
Coordinates 1633984..1634418 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5P8JE31
Locus tag F8A10_RS08190 Protein ID WP_018000085.1
Coordinates 1634415..1634654 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8A10_RS08160 1629907..1630362 - 456 WP_152367088.1 DUF2924 domain-containing protein -
F8A10_RS08170 1630696..1632858 + 2163 WP_152367089.1 hypothetical protein -
F8A10_RS08175 1632952..1633182 + 231 WP_018000087.1 hypothetical protein -
F8A10_RS08180 1633280..1633996 + 717 WP_062563252.1 sigma-70 family RNA polymerase sigma factor -
F8A10_RS08185 1633984..1634418 - 435 WP_011748362.1 type II toxin-antitoxin system VapC family toxin Toxin
F8A10_RS08190 1634415..1634654 - 240 WP_018000085.1 Arc family DNA-binding protein Antitoxin
F8A10_RS08195 1634778..1634978 + 201 WP_152367090.1 hypothetical protein -
F8A10_RS08200 1634975..1637200 + 2226 WP_152367091.1 AAA family ATPase -
F8A10_RS08205 1637576..1637776 + 201 WP_104492639.1 hypothetical protein -
F8A10_RS08210 1637769..1638146 + 378 WP_152367092.1 helix-turn-helix domain-containing protein -
F8A10_RS08215 1638289..1638633 + 345 WP_152367093.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Arc-like DNA binding domain

(3-42)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15536.75 Da        Isoelectric Point: 4.5849

>T141179 WP_011748362.1 NZ_CP045072:c1634418-1633984 [Paracoccus kondratievae]
MIILDTNVVSETMKPAPEPRVIDWLNRQELTTLHLTTISLAELRFGIACLDAGRRRDDLDARLEQMLAEVFPARILSFDE
AAASAFGVLMATARRQGQAVSFADGAIAAIAAAQGYPVASRDTAPFAAMGVEVVDPWHEAAQGR

Download         Length: 435 bp

>T141179 NZ_CP059849:c4765919-4765545 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCTATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8686.79 Da        Isoelectric Point: 5.7012

>AT141179 WP_018000085.1 NZ_CP045072:c1634654-1634415 [Paracoccus kondratievae]
MAQIVVRQIPEEVHRALKAQAAAHGRSAEAELREIIARAVLPQSRPRAGDLMRSIWSGAETDDLSVERDRTPAEPAGFE

Download         Length: 240 bp

>AT141179 NZ_CP059849:c4766161-4765919 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P8JDY4

Antitoxin

Source ID Structure
AlphaFold DB A0A5P8JE31

References