Detailed information of TA system TA141178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 696348..696877
• Replicon: chromosome
• Accession: NZ_CP045072
• Organism: Paracoccus kondratievae strain BJQ0001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: F8A10_RS03560
• Protein ID: WP_152366699.1
• Coordinates: 696348..696635 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: F8A10_RS03565
• Protein ID: WP_152366700.1
• Coordinates: 696632..696877 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8A10_RS03520	692065..692283	-	219	WP_072461783.1	helix-turn-helix domain-containing protein	-
F8A10_RS03525	692610..692933	+	324	WP_152366693.1	zinc ribbon domain-containing protein	-
F8A10_RS03530	692930..693112	+	183	WP_028717528.1	hypothetical protein	-
F8A10_RS03535	693109..693618	+	510	WP_152366694.1	hypothetical protein	-
F8A10_RS03540	693615..693893	+	279	WP_152366695.1	hypothetical protein	-
F8A10_RS03545	694035..694244	+	210	WP_152366696.1	hypothetical protein	-
F8A10_RS03550	694572..695744	+	1173	WP_152366697.1	ATP-binding protein	-
F8A10_RS03555	695966..696259	-	294	WP_152366698.1	hypothetical protein	-
F8A10_RS03560	696348..696635	-	288	WP_152366699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F8A10_RS03565	696632..696877	-	246	WP_152366700.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
F8A10_RS03570	696982..698343	-	1362	WP_152366701.1	plasmid recombination protein	-
F8A10_RS03575	698336..699433	-	1098	WP_152366702.1	hypothetical protein	-
F8A10_RS03585	699902..700924	+	1023	WP_010398125.1	LacI family DNA-binding transcriptional regulator	-
F8A10_RS03590	700971..701774	-	804	WP_152366703.1	type I methionyl aminopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10638.11 Da
• Isoelectric Point: 6.4738

>T141178 WP_152366699.1 NZ_CP045072:c696635-696348 [Paracoccus kondratievae]
MKALAFTVAATVDLEAIWDYTEGEWGLAQARRYVQELRDTCHALASGQGRGRPVDVRPGYLKCLSGSHVIFFRDLGDTLE
IVRILHGAQDVERHL

Nucleotide

• Length: 288 bp

>T141178 NZ_CP059849:3680262-3680480 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACTATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8810.88 Da
• Isoelectric Point: 7.2038

>AT141178 WP_152366700.1 NZ_CP045072:c696877-696632 [Paracoccus kondratievae]
MSRNTSVSLGDHFVSFIDTQVKGGRYGSASDVVRAGLRLLEEHETKVKALQDALIAGEESGRAEGFDLDRFIARKMAGRN
A

Nucleotide

• Length: 246 bp

>AT141178 NZ_CP059849:3679860-3680234 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA