Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1274575..1275122 | Replicon | chromosome |
| Accession | NZ_CP045070 | ||
| Organism | Vibrio harveyi strain WXL538 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | F9277_RS06815 | Protein ID | WP_152163267.1 |
| Coordinates | 1274820..1275122 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A454B3H2 |
| Locus tag | F9277_RS06810 | Protein ID | WP_005445660.1 |
| Coordinates | 1274575..1274832 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F9277_RS06750 | 1269661..1269954 | + | 294 | WP_050940193.1 | hypothetical protein | - |
| F9277_RS06755 | 1270022..1270111 | + | 90 | WP_193222960.1 | DUF3265 domain-containing protein | - |
| F9277_RS06760 | 1270272..1270791 | + | 520 | Protein_1240 | DUF2778 domain-containing protein | - |
| F9277_RS06765 | 1270781..1271149 | + | 369 | WP_152163265.1 | DUF2195 family protein | - |
| F9277_RS28575 | 1271671..1271787 | + | 117 | Protein_1242 | DUF3265 domain-containing protein | - |
| F9277_RS06775 | 1271904..1272371 | + | 468 | WP_127891310.1 | hypothetical protein | - |
| F9277_RS06785 | 1272632..1272910 | + | 279 | Protein_1244 | BrnT family toxin | - |
| F9277_RS06790 | 1272934..1273113 | + | 180 | WP_017190351.1 | hypothetical protein | - |
| F9277_RS06795 | 1273534..1273968 | + | 435 | WP_152163266.1 | hypothetical protein | - |
| F9277_RS06800 | 1273947..1274381 | + | 435 | WP_005445664.1 | hypothetical protein | - |
| F9277_RS06805 | 1274392..1274493 | + | 102 | WP_100216259.1 | DUF3265 domain-containing protein | - |
| F9277_RS06810 | 1274575..1274832 | + | 258 | WP_005445660.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| F9277_RS06815 | 1274820..1275122 | + | 303 | WP_152163267.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| F9277_RS06820 | 1275166..1275318 | - | 153 | Protein_1251 | IS30 family transposase | - |
| F9277_RS06825 | 1275411..1275638 | + | 228 | WP_017190347.1 | type II toxin-antitoxin system YafO family toxin | - |
| F9277_RS06830 | 1275647..1275849 | + | 203 | Protein_1253 | hypothetical protein | - |
| F9277_RS06835 | 1275904..1276032 | + | 129 | WP_086028312.1 | DUF3265 domain-containing protein | - |
| F9277_RS06845 | 1276713..1277144 | + | 432 | WP_050903108.1 | GNAT family N-acetyltransferase | - |
| F9277_RS06860 | 1278387..1278638 | + | 252 | WP_152163268.1 | DUF2442 domain-containing protein | - |
| F9277_RS06870 | 1279304..1279549 | + | 246 | WP_017817976.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1171053..1281181 | 110128 | |
| - | inside | Integron | - | - | 1169841..1274832 | 104991 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11602.50 Da Isoelectric Point: 5.8527
>T141177 WP_152163267.1 NZ_CP045070:1274820-1275122 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTSFSKVERLQTFPESGRIPPDLKHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLCKFLLNKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTSFSKVERLQTFPESGRIPPDLKHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLCKFLLNKQ
Download Length: 303 bp
>T141177 NZ_CP059849:2512142-2512627 [Citrobacter freundii]
GTGGGATGTGTAACAGCACCAGAACCTTTATCCAGTTTCCATCAGGTGGTGGAGTTTGTTAGCGGTAAAGCTGTGCTCGA
TGACTGGTTAAAGCAAAGAGGTCTCAAAAACCAGGCACTCGGAGCTGCCCGAACTTTTGTTGTTTGCAAGAAAGACACAA
AACAAGCGGCTGGTTTTTACTCTCTGGCCACTGGTAGCGTCAACCATGCAGAAGCAACAGGCAGTTTTCGACGCAACATG
CCAGACCCCATTCCTGTCATCATACTAGCCCGTCTGGCTGTCGATCTCTCGTTTCATGGAAAAGGGCTTGATGCTGATTT
GCTACACGATGCTGTACTCCGTTGCTATCGAGTTGCTCAGAATATCGGTGTACGTGCAATCATGGTTCACGCGCTTACGG
AAGAAGCTAAAAATTTCTATATTCACCATGGTTTCAAGCCATCACAAACTCAGCAGCGAACATTGTTCCTTAAACTCCCT
CAATAA
GTGGGATGTGTAACAGCACCAGAACCTTTATCCAGTTTCCATCAGGTGGTGGAGTTTGTTAGCGGTAAAGCTGTGCTCGA
TGACTGGTTAAAGCAAAGAGGTCTCAAAAACCAGGCACTCGGAGCTGCCCGAACTTTTGTTGTTTGCAAGAAAGACACAA
AACAAGCGGCTGGTTTTTACTCTCTGGCCACTGGTAGCGTCAACCATGCAGAAGCAACAGGCAGTTTTCGACGCAACATG
CCAGACCCCATTCCTGTCATCATACTAGCCCGTCTGGCTGTCGATCTCTCGTTTCATGGAAAAGGGCTTGATGCTGATTT
GCTACACGATGCTGTACTCCGTTGCTATCGAGTTGCTCAGAATATCGGTGTACGTGCAATCATGGTTCACGCGCTTACGG
AAGAAGCTAAAAATTTCTATATTCACCATGGTTTCAAGCCATCACAAACTCAGCAGCGAACATTGTTCCTTAAACTCCCT
CAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9548.06 Da Isoelectric Point: 7.3177
>AT141177 WP_005445660.1 NZ_CP045070:1274575-1274832 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKGKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKGKM
SKWLK
Download Length: 258 bp
>AT141177 NZ_CP059849:2511888-2512154 [Citrobacter freundii]
ATGAAATCAGATGTTCAACTCAACCTTAGAGCCAAGGAATCACAGCGAGCGCTCATTGATGCCGCTGCGGAAATCCTCCA
CAAATCTCGCACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCCTTGATCGTCGTGTCTTTAATT
TTAGCGATGAGCAATATGCAGAGTTTATCGATATGCTTGATGCACCGGTTGCGGATGATCCTATTATCGACAAACTGCTG
GCAAGGAAACCGCAGTGGGATGTGTAA
ATGAAATCAGATGTTCAACTCAACCTTAGAGCCAAGGAATCACAGCGAGCGCTCATTGATGCCGCTGCGGAAATCCTCCA
CAAATCTCGCACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCCTTGATCGTCGTGTCTTTAATT
TTAGCGATGAGCAATATGCAGAGTTTATCGATATGCTTGATGCACCGGTTGCGGATGATCCTATTATCGACAAACTGCTG
GCAAGGAAACCGCAGTGGGATGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|