Detailed information of TA system TA141175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1217621..1218180
• Replicon: chromosome
• Accession: NZ_CP045070
• Organism: Vibrio harveyi strain WXL538

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9277_RS06120
• Protein ID: WP_038882476.1
• Coordinates: 1217621..1217899 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: F9277_RS06125
• Protein ID: WP_005398409.1
• Coordinates: 1217896..1218180 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9277_RS06055	1212833..1213450	+	618	Protein_1111	PH domain-containing protein	-
F9277_RS06060	1213489..1213581	+	93	WP_075111228.1	DUF3265 domain-containing protein	-
F9277_RS06065	1213610..1214383	+	774	WP_152163222.1	NERD domain-containing protein	-
F9277_RS06070	1214398..1214490	+	93	WP_193222936.1	DUF3265 domain-containing protein	-
F9277_RS06075	1214569..1214892	-	324	WP_152163223.1	hypothetical protein	-
F9277_RS06080	1214979..1215110	+	132	WP_017821410.1	DUF3265 domain-containing protein	-
F9277_RS06085	1215147..1215917	+	771	WP_029863063.1	hypothetical protein	-
F9277_RS06090	1215932..1216024	+	93	WP_080252015.1	DUF3265 domain-containing protein	-
F9277_RS06100	1216513..1216644	+	132	WP_080374022.1	DUF3265 domain-containing protein	-
F9277_RS06105	1216666..1216929	+	264	WP_045421363.1	hypothetical protein	-
F9277_RS06110	1216952..1217044	+	93	WP_071936844.1	DUF3265 domain-containing protein	-
F9277_RS06120	1217621..1217899	-	279	WP_038882476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
F9277_RS06125	1217896..1218180	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F9277_RS06130	1218257..1218348	+	92	Protein_1124	DUF3265 domain-containing protein	-
F9277_RS06135	1218423..1218680	+	258	WP_152163224.1	hypothetical protein	-
F9277_RS06140	1218864..1220087	+	1224	WP_152163225.1	hypothetical protein	-
F9277_RS06145	1220059..1220223	+	165	WP_152163226.1	DUF3265 domain-containing protein	-
F9277_RS06150	1220249..1220716	+	468	WP_152163227.1	hypothetical protein	-
F9277_RS06155	1220852..1221379	+	528	WP_152163228.1	CbrC family protein	-
F9277_RS06160	1221502..1222650	+	1149	WP_152163229.1	DUF4236 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1171053..1281181	110128
	-	inside	Integron	-	-	1169841..1274832	104991

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10905.60 Da
• Isoelectric Point: 4.3430

>T141175 WP_038882476.1 NZ_CP045070:c1217899-1217621 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGLQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T141175 NZ_CP059849:2001213-2001316 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT141175 WP_005398409.1 NZ_CP045070:c1218180-1217896 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT141175 NZ_CP059849:c2001321-2001178 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: A0A347UR21