Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1200954..1201513 Replicon chromosome
Accession NZ_CP045070
Organism Vibrio harveyi strain WXL538

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag F9277_RS05910 Protein ID WP_005398411.1
Coordinates 1200954..1201232 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag F9277_RS05915 Protein ID WP_005398409.1
Coordinates 1201229..1201513 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9277_RS05845 1196045..1196137 + 93 WP_078555105.1 DUF3265 domain-containing protein -
F9277_RS05850 1196164..1196556 + 393 WP_152163205.1 hypothetical protein -
F9277_RS28510 1196571..1196663 + 93 WP_193222934.1 DUF3265 domain-containing protein -
F9277_RS05860 1196692..1197465 + 774 WP_152163207.1 NERD domain-containing protein -
F9277_RS05865 1197480..1197572 + 93 WP_004748931.1 DUF3265 domain-containing protein -
F9277_RS05870 1197603..1198040 + 438 WP_152163208.1 NUDIX pyrophosphatase -
F9277_RS05880 1198205..1198849 + 645 WP_061065143.1 glutathione S-transferase family protein -
F9277_RS05885 1198864..1198956 + 93 WP_005448619.1 DUF3265 domain-containing protein -
F9277_RS05890 1199529..1200173 + 645 WP_152163209.1 hypothetical protein -
F9277_RS05895 1200203..1200295 + 93 WP_079767272.1 DUF3265 domain-containing protein -
F9277_RS05900 1200324..1200818 + 495 WP_152163211.1 DUF695 domain-containing protein -
F9277_RS05905 1200833..1200925 + 93 WP_017790380.1 DUF3265 domain-containing protein -
F9277_RS05910 1200954..1201232 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
F9277_RS05915 1201229..1201513 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F9277_RS05920 1201781..1202212 + 432 WP_152163212.1 GNAT family N-acetyltransferase -
F9277_RS05925 1202446..1202787 + 342 WP_045372035.1 hypothetical protein -
F9277_RS05930 1202814..1202906 + 93 WP_140138454.1 DUF3265 domain-containing protein -
F9277_RS05935 1202933..1203343 + 411 WP_042773624.1 hydrolase -
F9277_RS05940 1203336..1203467 + 132 WP_152163213.1 DUF3265 domain-containing protein -
F9277_RS05945 1203494..1203913 + 420 WP_045459106.1 hypothetical protein -
F9277_RS05950 1203938..1204027 + 90 WP_078235976.1 DUF3265 domain-containing protein -
F9277_RS05955 1204054..1204461 + 408 WP_152163214.1 hypothetical protein -
F9277_RS05960 1204490..1204579 + 90 WP_072615037.1 DUF3265 domain-containing protein -
F9277_RS05965 1204626..1205006 + 381 WP_045390239.1 hypothetical protein -
F9277_RS28515 1205146..1205289 + 144 WP_155397170.1 hypothetical protein -
F9277_RS05970 1205308..1205694 + 387 WP_029791167.1 type II toxin-antitoxin system YafO family toxin -
F9277_RS05975 1205694..1205999 + 306 WP_017191351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1171053..1281181 110128
- inside Integron - - 1169841..1274832 104991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T141174 WP_005398411.1 NZ_CP045070:c1201232-1200954 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T141174 NZ_CP059849:c1429259-1428999 [Citrobacter freundii]
ATGAAAGTCAGGATATCCCCGCAGGCAAAAAGCGATCTTCAATACTGGGCCGAGACTGACCCAAAGACGCATAACAAAGT
AATGGAGTTAATCAAATCGGCTAAGGAAAGCCCCTTCAAGGGGATAGGGAAACCGGAGGCGCTAAAGCACCGTAAGCCCC
TCTGGTCACGTCGCATCACAAAAGAACATCGCCTGGTGTACTACGTTGAGCAAGGCGATCTGTACATTGTCGCGTGTCGT
TATCACTACACCACGATCTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT141174 WP_005398409.1 NZ_CP045070:c1201513-1201229 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT141174 NZ_CP059849:c1429504-1429259 [Citrobacter freundii]
ATGCAACACGTAAACTATACCGATGCTCGACAGCATTTAGCTGACCTGATGCAGCAGGCTAATGATGATCGTGCGCCAAT
CCTGGTTACTCGTAAGGGTGCTAAAAGCGTGGTAATGATCGACGCGGAAGAGTTCGCATCGATTCAGGAAACGTTACATC
TGTTCAGTAATCCGGCGAACGCCGCACACATTGAAGCCAGCCTTGCATCACTCGAACGCGGCGATTATGAGGAACTGGAC
ATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References