Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 4747201..4747998 Replicon chromosome
Accession NZ_CP045064
Organism Enterobacter roggenkampii strain WCHER090065

Toxin (Protein)


Gene name ataT Uniprot ID A0A855M5A0
Locus tag GIX98_RS22860 Protein ID WP_025912981.1
Coordinates 4747477..4747998 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag GIX98_RS22855 Protein ID WP_008499829.1
Coordinates 4747201..4747470 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIX98_RS22825 4742824..4743267 - 444 WP_008499834.1 helix-turn-helix transcriptional regulator -
GIX98_RS22830 4743420..4744661 + 1242 WP_058654606.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
GIX98_RS22835 4744697..4744924 - 228 WP_008499832.1 YccJ family protein -
GIX98_RS22840 4744945..4745541 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
GIX98_RS22845 4745933..4746103 + 171 WP_013097201.1 general stress protein -
GIX98_RS22850 4746222..4747139 + 918 WP_025912980.1 DMT family transporter -
GIX98_RS22855 4747201..4747470 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
GIX98_RS22860 4747477..4747998 + 522 WP_025912981.1 GNAT family N-acetyltransferase Toxin
GIX98_RS22865 4748072..4749394 - 1323 WP_008499826.1 pyrimidine utilization transport protein G -
GIX98_RS22870 4749416..4749910 - 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
GIX98_RS22875 4749920..4750510 - 591 WP_008499824.1 malonic semialdehyde reductase -
GIX98_RS22880 4750520..4751320 - 801 WP_021240807.1 pyrimidine utilization protein D -
GIX98_RS22885 4751328..4751714 - 387 WP_008499822.1 pyrimidine utilization protein C -
GIX98_RS22890 4751726..4752415 - 690 WP_058654604.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19697.52 Da        Isoelectric Point: 7.9331

>T141172 WP_025912981.1 NZ_CP045064:4747477-4747998 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYNFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTVENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

>T141172 NZ_CP059849:44529-44891 [Citrobacter freundii]
ATGTGGGAAGTGGAAACAACGGATGCTTTCGATAAATGGTTTGACGTACAGACCGAAGCGCTCAAGGAAGATATGCTCGC
AGCAATGATGATTTTATCCGAGTGTGGTCCTCAGTTAGGTAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTACAGCATCAGGGTAGTCCGATTCGGGCGTTCTTCGCGTTTGATCCTTCTCGCCATGGCATC
GTGCTATGCGCTGGAGATAAAACAGGGTTAAACGAAAAGAAATTCTATAAAGAGATGATCAGGCTTGCGGATGCTGAGTA
CCGAAATCACCTAATAAGTAAGGAAAATTATGGCTACCCTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT141172 WP_008499829.1 NZ_CP045064:4747201-4747470 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT141172 NZ_CP059849:44878-45177 [Citrobacter freundii]
ATGGCTACCCTTAAAGAATTGATGGCGAAACAAAGCCCGGAAAGCCAGGAGCGTATTACCGAAAAAGTAGAAATACTACG
TCAGGCGGTTGCGTTAAATATGTTAAGGGAAGAACTGAATCTCTCTCAGGCTGAACTTGCCTCGGCAATGGGGGTTAAGC
AGCCAACAATCGCAAAAATGGAGCAGGCAGATAACGATCCTCGTCTGTCGACGCTCAAGCGTTATGTCACGGCACTGGGT
GGTGAACTTAGCATTGATGTTAAGCTACCTACAGGTAAAAGAGTCGCGTTCTATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855M5A0

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References