Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4136745..4137365 Replicon chromosome
Accession NZ_CP045064
Organism Enterobacter roggenkampii strain WCHER090065

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag GIX98_RS19940 Protein ID WP_008499287.1
Coordinates 4136745..4136963 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag GIX98_RS19945 Protein ID WP_008499288.1
Coordinates 4136991..4137365 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIX98_RS19910 4132758..4133018 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
GIX98_RS19915 4133021..4133161 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GIX98_RS19920 4133158..4133868 - 711 WP_058655062.1 GNAT family N-acetyltransferase -
GIX98_RS19925 4133970..4135430 + 1461 WP_023343501.1 PLP-dependent aminotransferase family protein -
GIX98_RS19930 4135402..4135869 - 468 WP_008499285.1 membrane protein -
GIX98_RS19935 4135987..4136538 - 552 WP_008499286.1 maltose O-acetyltransferase -
GIX98_RS19940 4136745..4136963 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
GIX98_RS19945 4136991..4137365 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
GIX98_RS19950 4137875..4141021 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
GIX98_RS19955 4141044..4142237 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T141171 WP_008499287.1 NZ_CP045064:c4136963-4136745 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T141171 NZ_CP059843:2806372-2806836 [Cobetia sp. 4B]
ATGACTGTGGTGCGCGGTTATCGGCTCGTTAAGCGGAAGTGGCTAAAGACAGCCTTTGATGGGGAAGGGGCTCGGCTGTA
CGGCGGGCGCTGGAACAGCAAAGGCAAGGCCTGTGTGTACCTCGCGAGCACAGAGTCATTGGCCATGCTCGAGGTGATGG
TTCACCTGGAAGACAATCAGCTGCTGAAGGAGTATGCGCTCCTGGAGGTGACATTCCGGGAGGAGGTGCTAATGCAGCTC
CCGGAGGACGTTCTGCCAGCAGATTGGCGAGCTGAGCCGGCGCCACCCTCCACAGCCGAGATCGGTGACGACTGGCTTGA
GGGACAGTCGAGCCTAGTTCTGGCGGTTCCGAGTGTGGTCGCGCCCCGAGAAACGAACTACCTCGTTAATCCAGAGCACC
CCGCTTTTCTGGCGCTGGCCCAGGGTGCCGAAGAGGTCGATTTCACTCCAGATCGTCGCCTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT141171 WP_008499288.1 NZ_CP045064:c4137365-4136991 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT141171 NZ_CP059843:2805923-2806375 [Cobetia sp. 4B]
ATGCAAGCCGCTATCAAAGAGTATCGCCCAAAACCAGCCGCTCGGAAGGACGACTTCTGGAGGGCTCTGGGTCTTCCCTC
GCGTGGAGCCAAGCTGCATGAAGCGCTGAATGCTGGCATCTCGTACAAAGTCTATACCAAGCTCACTGAGGCCTCCGGGC
TTGAGAGCAAGGAGTTGGCACGGTATGTGGTCATTCCTCCGGCAACCCTGAAGCGTCGTGCCGATACTGGCTACTTCAAA
CCTGCCGAGGGCGATCGACTTTACCGTTTCGCTGAGGTGTACAAGAGCGCGGTGGACCTGTTCGAAGGCGACAAGGCGAA
GGCGAAAGAATGGTTGCTCAGCCCCGTGCGTGGGCTGGGGGGGCGTCTACCGGTCGAGATGGTGGCTACCACTGCTGGCG
CCGAAGCCGTTCTAGATCTGATCGGCCGGCTTGAGCATGGCGTCTTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References