Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2658245..2658841 Replicon chromosome
Accession NZ_CP045064
Organism Enterobacter roggenkampii strain WCHER090065

Toxin (Protein)


Gene name PumA Uniprot ID A0A855LXZ0
Locus tag GIX98_RS12880 Protein ID WP_058653792.1
Coordinates 2658245..2658547 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag GIX98_RS12885 Protein ID WP_021242718.1
Coordinates 2658554..2658841 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIX98_RS12860 2654227..2655801 + 1575 WP_058653793.1 RNA repair transcriptional activator RtcR -
GIX98_RS12865 2655907..2656851 + 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
GIX98_RS12870 2656902..2657174 + 273 WP_014830263.1 DUF3811 domain-containing protein -
GIX98_RS12875 2657175..2658047 - 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
GIX98_RS12880 2658245..2658547 + 303 WP_058653792.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GIX98_RS12885 2658554..2658841 + 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
GIX98_RS12890 2658838..2660469 - 1632 WP_008503411.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11485.27 Da        Isoelectric Point: 10.0625

>T141169 WP_058653792.1 NZ_CP045064:2658245-2658547 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIYFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T141169 NZ_CP059841:c77749-77219 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGGTTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGATTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTGATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT141169 WP_021242718.1 NZ_CP045064:2658554-2658841 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT141169 NZ_CP059841:c78022-77753 [Escherichia coli]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAATCTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855LXZ0

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References