Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2254609..2255362 Replicon chromosome
Accession NZ_CP045064
Organism Enterobacter roggenkampii strain WCHER090065

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag GIX98_RS10885 Protein ID WP_025799003.1
Coordinates 2254985..2255362 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag GIX98_RS10880 Protein ID WP_072269511.1
Coordinates 2254609..2254935 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIX98_RS10860 2250017..2253172 + 3156 WP_077267777.1 AIDA repeat-containing protein -
GIX98_RS10865 2253395..2253826 + 432 WP_088903392.1 antirestriction protein -
GIX98_RS10870 2253838..2254317 + 480 WP_025798999.1 DNA repair protein RadC -
GIX98_RS10875 2254331..2254552 + 222 WP_045888217.1 DUF987 domain-containing protein -
GIX98_RS10880 2254609..2254935 + 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GIX98_RS10885 2254985..2255362 + 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
GIX98_RS10890 2255359..2255850 + 492 WP_045888216.1 hypothetical protein -
GIX98_RS10895 2255879..2256082 + 204 WP_025799007.1 DUF957 domain-containing protein -
GIX98_RS10900 2256164..2257009 + 846 WP_025799009.1 DUF4942 domain-containing protein -
GIX98_RS10910 2257312..2257818 + 507 WP_008503183.1 G/U mismatch-specific DNA glycosylase -
GIX98_RS10915 2257909..2259756 - 1848 WP_008503184.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T141168 WP_025799003.1 NZ_CP045064:2254985-2255362 [Enterobacter roggenkampii]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T141168 NZ_CP059841:c72648-72343 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT141168 WP_072269511.1 NZ_CP045064:2254609-2254935 [Enterobacter roggenkampii]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT141168 NZ_CP059841:c72868-72650 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGTGGAAAATCAGGAAGGGATGGTTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References