Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2038392..2039049 Replicon chromosome
Accession NZ_CP045064
Organism Enterobacter roggenkampii strain WCHER090065

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag GIX98_RS09940 Protein ID WP_021242050.1
Coordinates 2038392..2038802 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag GIX98_RS09945 Protein ID WP_006178375.1
Coordinates 2038783..2039049 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GIX98_RS09920 2034385..2036118 - 1734 WP_008499707.1 single-stranded-DNA-specific exonuclease RecJ -
GIX98_RS09925 2036124..2036837 - 714 WP_058653964.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GIX98_RS09930 2036866..2037762 - 897 WP_008499709.1 site-specific tyrosine recombinase XerD -
GIX98_RS09935 2037864..2038385 + 522 WP_058653965.1 flavodoxin FldB -
GIX98_RS09940 2038392..2038802 - 411 WP_021242050.1 protein YgfX Toxin
GIX98_RS09945 2038783..2039049 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
GIX98_RS09950 2039344..2040324 + 981 WP_058653966.1 tRNA-modifying protein YgfZ -
GIX98_RS09955 2040409..2041068 - 660 WP_021242052.1 hemolysin III family protein -
GIX98_RS09960 2041334..2042065 + 732 WP_008499714.1 MurR/RpiR family transcriptional regulator -
GIX98_RS09965 2042182..2043615 + 1434 WP_008499715.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T141167 WP_021242050.1 NZ_CP045064:c2038802-2038392 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T141167 NZ_CP059841:24522-24920 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT141167 WP_006178375.1 NZ_CP045064:c2039049-2038783 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT141167 NZ_CP059841:24295-24522 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References