Detailed information of TA system TA141157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 222698..223254
• Replicon: plasmid pLG26p2
• Accession: NZ_CP045061
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG26

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3R0U7A1
• Locus tag: SMLG26_RS01405
• Protein ID: WP_000404186.1
• Coordinates: 222979..223254 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SMLG26_RS01400
• Protein ID: WP_065314520.1
• Coordinates: 222698..222979 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG26_RS01395	221875..222615	+	741	WP_057395086.1	conjugal transfer pilus acetylase TraX	-
SMLG26_RS01400	222698..222979	+	282	WP_065314520.1	ribbon-helix-helix protein, CopG family	Antitoxin
SMLG26_RS01405	222979..223254	+	276	WP_000404186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMLG26_RS01410	223292..223855	+	564	WP_057395085.1	fertility inhibition protein FinO	-
SMLG26_RS01415	224174..224434	+	261	WP_097361646.1	hypothetical protein	-
SMLG26_RS01420	224988..225332	+	345	WP_057395081.1	hypothetical protein	-
SMLG26_RS01425	225364..225687	+	324	WP_023223027.1	PerC family transcriptional regulator	-
SMLG26_RS01430	225681..226052	+	372	Protein_245	hypothetical protein	-
SMLG26_RS01435	226241..226447	+	207	WP_023223029.1	hemolysin expression modulator Hha	-
SMLG26_RS25925	226577..226794	+	218	Protein_247	DUF465 domain-containing protein	-
SMLG26_RS01445	227094..227915	+	822	WP_057395079.1	thioredoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..270863	270863

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-65)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T141157 WP_000404186.1 NZ_CP045061:222979-223254 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T141157 NZ_CP059840:2499994-2500272 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>AT141157 WP_065314520.1 NZ_CP045061:222698-222979 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>AT141157 NZ_CP059840:2500272-2500556 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCTGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Structures

Toxin

• AlphaFold DB: A0A3R0U7A1