Detailed information of TA system TA141154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 23968..24521
• Replicon: plasmid pLG26p1
• Accession: NZ_CP045060
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG26

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: SMLG26_RS00145
• Protein ID: WP_057394242.1
• Coordinates: 23968..24282 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: SMLG26_RS00150
• Protein ID: WP_057394243.1
• Coordinates: 24285..24521 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG26_RS00115	20416..20673	-	258	WP_153789508.1	hypothetical protein	-
SMLG26_RS00120	20697..20930	-	234	WP_004178129.1	hypothetical protein	-
SMLG26_RS00125	20971..21618	-	648	WP_153789509.1	ParA family protein	-
SMLG26_RS00130	21738..22520	-	783	WP_153789510.1	sprT domain-containing protein	-
SMLG26_RS00135	22956..23234	+	279	WP_048044186.1	type II toxin-antitoxin system HicA family toxin	-
SMLG26_RS00140	23227..23574	+	348	WP_153789511.1	type II toxin-antitoxin system HicB family antitoxin	-
SMLG26_RS00145	23968..24282	-	315	WP_057394242.1	CcdB family protein	Toxin
SMLG26_RS00150	24285..24521	-	237	WP_057394243.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
SMLG26_RS00155	24632..24865	-	234	WP_153789512.1	XRE family transcriptional regulator	-
SMLG26_RS00160	24855..25112	-	258	WP_153789513.1	hypothetical protein	-
SMLG26_RS00165	25109..25309	-	201	WP_153789514.1	hypothetical protein	-
SMLG26_RS00170	25423..25938	-	516	WP_153789515.1	J domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..26056	26056

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 15471.56 Da
• Isoelectric Point: 5.5500

>T141154 WP_057394242.1 NZ_CP045060:c24282-23968 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 315 bp

>T141154 NZ_CP059840:1954664-1954918 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 11644.97 Da
• Isoelectric Point: 5.5500

>AT141154 WP_057394243.1 NZ_CP045060:c24521-24285 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 237 bp

>AT141154 NZ_CP059840:1954416-1954667 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA