Detailed information of TA system TA141153

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 233439..233974
• Replicon: plasmid pLG25p2
• Accession: NZ_CP045058
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SMLG25_RS01480
• Protein ID: WP_097361649.1
• Coordinates: 233687..233974 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SMLG25_RS01475
• Protein ID: WP_057394760.1
• Coordinates: 233439..233690 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG25_RS01445	229065..229610	+	546	WP_153789535.1	phospholipase D family protein	-
SMLG25_RS01450	229748..230005	+	258	WP_057395075.1	replication regulatory protein RepA	-
SMLG25_RS01455	230237..230311	+	75	WP_071529947.1	RepA leader peptide Tap	-
SMLG25_RS01460	230304..231320	+	1017	WP_097361647.1	replication initiation protein	-
SMLG25_RS01465	232196..232588	-	393	WP_097361648.1	nuclear transport factor 2 family protein	-
SMLG25_RS01470	233079..233352	-	274	Protein_255	recombinase family protein	-
SMLG25_RS01475	233439..233690	+	252	WP_057394760.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SMLG25_RS01480	233687..233974	+	288	WP_097361649.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMLG25_RS01485	233979..234209	+	231	WP_057394395.1	hypothetical protein	-
SMLG25_RS01490	234365..234607	+	243	WP_057394396.1	hypothetical protein	-
SMLG25_RS01495	234725..234961	-	237	WP_176193362.1	hypothetical protein	-
SMLG25_RS25680	236084..236839	+	756	WP_176193363.1	hypothetical protein	-
SMLG25_RS01505	236889..237419	-	531	WP_071497240.1	colicin immunity protein Cui	-
SMLG25_RS01510	237478..237909	-	432	WP_057393438.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..270878	270878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 12322.73 Da
• Isoelectric Point: 12.7777

>T141153 WP_097361649.1 NZ_CP045058:233687-233974 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Nucleotide

• Length: 288 bp

>T141153 NZ_CP059840:1954416-1954667 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT141153 WP_057394760.1 NZ_CP045058:233439-233690 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT141153 NZ_CP059840:1954664-1954918 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA