Detailed information of TA system TA141152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 222711..223267
• Replicon: plasmid pLG25p2
• Accession: NZ_CP045058
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3R0U7A1
• Locus tag: SMLG25_RS01395
• Protein ID: WP_000404186.1
• Coordinates: 222992..223267 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SMLG25_RS01390
• Protein ID: WP_065314520.1
• Coordinates: 222711..222992 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG25_RS01385	221888..222628	+	741	WP_057395086.1	conjugal transfer pilus acetylase TraX	-
SMLG25_RS01390	222711..222992	+	282	WP_065314520.1	ribbon-helix-helix protein, CopG family	Antitoxin
SMLG25_RS01395	222992..223267	+	276	WP_000404186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMLG25_RS01400	223305..223868	+	564	WP_057395085.1	fertility inhibition protein FinO	-
SMLG25_RS01405	224187..224447	+	261	WP_097361646.1	hypothetical protein	-
SMLG25_RS01410	225001..225345	+	345	WP_057395081.1	hypothetical protein	-
SMLG25_RS01415	225377..225700	+	324	WP_023223027.1	PerC family transcriptional regulator	-
SMLG25_RS01420	225694..226065	+	372	Protein_245	hypothetical protein	-
SMLG25_RS01425	226254..226460	+	207	WP_023223029.1	hemolysin expression modulator Hha	-
SMLG25_RS25675	226590..226807	+	218	Protein_247	DUF465 domain-containing protein	-
SMLG25_RS01435	227107..227928	+	822	WP_057395079.1	thioredoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..270878	270878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11810.03 Da
• Isoelectric Point: 12.7590

>T141152 WP_000404186.1 NZ_CP045058:222992-223267 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Nucleotide

• Length: 276 bp

>T141152 NZ_CP059840:1106945-1107256 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>AT141152 WP_065314520.1 NZ_CP045058:222711-222992 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>AT141152 NZ_CP059840:1107253-1107672 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGTCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTATCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A3R0U7A1