Detailed information of TA system TA141151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 168781..169306
• Replicon: plasmid pLG25p2
• Accession: NZ_CP045058
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG25

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A5J1SSZ4
• Locus tag: SMLG25_RS01075
• Protein ID: WP_001159865.1
• Coordinates: 169001..169306 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: SMLG25_RS01070
• Protein ID: WP_079953237.1
• Coordinates: 168781..168999 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG25_RS01050	163980..164222	-	243	WP_057394653.1	type II toxin-antitoxin system ParD family antitoxin	-
SMLG25_RS01055	164483..165448	+	966	WP_057394652.1	DNA-binding protein	-
SMLG25_RS01060	165535..166302	+	768	WP_097361665.1	3'-5' exonuclease	-
SMLG25_RS01065	166981..168069	-	1089	WP_097361622.1	transcriptional regulator	-
SMLG25_RS01070	168781..168999	+	219	WP_079953237.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SMLG25_RS01075	169001..169306	+	306	WP_001159865.1	type II toxin-antitoxin system toxin CcdB	Toxin
SMLG25_RS01080	169308..169598	+	291	WP_097361623.1	cytoplasmic protein	-
SMLG25_RS01085	169595..170131	+	537	Protein_179	cytoplasmic protein	-
SMLG25_RS01090	170144..170926	+	783	WP_079953235.1	site-specific integrase	-
SMLG25_RS01095	171076..172005	-	930	WP_057394647.1	Rpn family recombination-promoting nuclease/putative transposase	-
SMLG25_RS01100	172420..173625	+	1206	WP_000427674.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..270878	270878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T141151 WP_001159865.1 NZ_CP045058:169001-169306 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T141151 NZ_CP059840:1037873-1038208 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCTCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT141151 WP_079953237.1 NZ_CP045058:168781-168999 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT141151 NZ_CP059840:1037625-1037873 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A5J1SSZ4