Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PrpT-parD/ParE-RHH
Location 163697..164222 Replicon plasmid pLG25p2
Accession NZ_CP045058
Organism Salmonella enterica subsp. enterica serovar Muenchen strain LG25

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag SMLG25_RS01045 Protein ID WP_079953242.1
Coordinates 163697..163987 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag SMLG25_RS01050 Protein ID WP_057394653.1
Coordinates 163980..164222 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMLG25_RS01015 158922..159227 - 306 WP_057394657.1 antibiotic biosynthesis monooxygenase -
SMLG25_RS01020 159304..160197 - 894 WP_153789529.1 hypothetical protein -
SMLG25_RS01025 160221..160409 - 189 WP_139760153.1 hypothetical protein -
SMLG25_RS01030 160442..161410 - 969 WP_153789530.1 MFS transporter -
SMLG25_RS01035 161422..162528 - 1107 WP_097361621.1 ThiF family adenylyltransferase -
SMLG25_RS01040 162774..163448 + 675 WP_057394654.1 metalloregulator ArsR/SmtB family transcription factor -
SMLG25_RS01045 163697..163987 - 291 WP_079953242.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMLG25_RS01050 163980..164222 - 243 WP_057394653.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SMLG25_RS01055 164483..165448 + 966 WP_057394652.1 DNA-binding protein -
SMLG25_RS01060 165535..166302 + 768 WP_097361665.1 3'-5' exonuclease -
SMLG25_RS01065 166981..168069 - 1089 WP_097361622.1 transcriptional regulator -
SMLG25_RS01070 168781..168999 + 219 WP_079953237.1 type II toxin-antitoxin system antitoxin CcdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..270878 270878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 14294.15 Da        Isoelectric Point: 5.5500

>T141150 WP_079953242.1 NZ_CP045058:c163987-163697 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFF

Download         Length: 291 bp

>T141150 NZ_CP059840:911446-911853 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 11939.32 Da        Isoelectric Point: 5.5500

>AT141150 WP_057394653.1 NZ_CP045058:c164222-163980 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
F

Download         Length: 243 bp

>AT141150 NZ_CP059840:911199-911465 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References