Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 23969..24522 Replicon plasmid pLG25p1
Accession NZ_CP045057
Organism Salmonella enterica subsp. enterica serovar Muenchen strain LG25

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag SMLG25_RS00145 Protein ID WP_057394242.1
Coordinates 23969..24283 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SMLG25_RS00150 Protein ID WP_057394243.1
Coordinates 24286..24522 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMLG25_RS00115 20419..20676 - 258 WP_153789508.1 hypothetical protein -
SMLG25_RS00120 20700..20933 - 234 WP_004178129.1 hypothetical protein -
SMLG25_RS00125 20974..21621 - 648 WP_153789509.1 ParA family protein -
SMLG25_RS00130 21740..22522 - 783 WP_153789510.1 sprT domain-containing protein -
SMLG25_RS00135 22957..23235 + 279 WP_048044186.1 type II toxin-antitoxin system HicA family toxin -
SMLG25_RS00140 23228..23575 + 348 WP_153789511.1 type II toxin-antitoxin system HicB family antitoxin -
SMLG25_RS00145 23969..24283 - 315 WP_057394242.1 CcdB family protein Toxin
SMLG25_RS00150 24286..24522 - 237 WP_057394243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SMLG25_RS00155 24633..24866 - 234 WP_153789512.1 XRE family transcriptional regulator -
SMLG25_RS00160 24856..25113 - 258 WP_153789513.1 hypothetical protein -
SMLG25_RS00165 25110..25310 - 201 WP_153789514.1 hypothetical protein -
SMLG25_RS00170 25424..25939 - 516 WP_153789515.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..26057 26057


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 15471.56 Da        Isoelectric Point: 5.5500

>T141149 WP_057394242.1 NZ_CP045057:c24283-23969 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 315 bp

>T141149 NZ_CP059840:310800-311075 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTGCGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 11644.97 Da        Isoelectric Point: 5.5500

>AT141149 WP_057394243.1 NZ_CP045057:c24522-24286 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 237 bp

>AT141149 NZ_CP059840:311072-311431 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References