Detailed information of TA system TA141148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 233442..233977
• Replicon: plasmid pLG24p2
• Accession: NZ_CP045054
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG24

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SMLG24_RS01475
• Protein ID: WP_097361649.1
• Coordinates: 233690..233977 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SMLG24_RS01470
• Protein ID: WP_057394760.1
• Coordinates: 233442..233693 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG24_RS01440	229068..229613	+	546	WP_153789535.1	phospholipase D family protein	-
SMLG24_RS01445	229751..230008	+	258	WP_057395075.1	replication regulatory protein RepA	-
SMLG24_RS01450	230240..230314	+	75	WP_071529947.1	RepA leader peptide Tap	-
SMLG24_RS01455	230307..231323	+	1017	WP_097361647.1	replication initiation protein	-
SMLG24_RS01460	232199..232591	-	393	WP_097361648.1	nuclear transport factor 2 family protein	-
SMLG24_RS01465	233082..233355	-	274	Protein_254	recombinase family protein	-
SMLG24_RS01470	233442..233693	+	252	WP_057394760.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SMLG24_RS01475	233690..233977	+	288	WP_097361649.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SMLG24_RS01480	233982..234212	+	231	WP_057394395.1	hypothetical protein	-
SMLG24_RS01485	234368..234610	+	243	WP_057394396.1	hypothetical protein	-
SMLG24_RS01490	234728..234964	-	237	WP_176193362.1	hypothetical protein	-
SMLG24_RS25925	236087..236842	+	756	WP_176193363.1	hypothetical protein	-
SMLG24_RS01500	236892..237422	-	531	WP_071497240.1	colicin immunity protein Cui	-
SMLG24_RS01505	237481..237912	-	432	WP_057393438.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..270881	270881

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 12322.73 Da
• Isoelectric Point: 12.7777

>T141148 WP_097361649.1 NZ_CP045054:233690-233977 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Nucleotide

• Length: 288 bp

>T141148 NZ_CP059840:234697-234804 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT141148 WP_057394760.1 NZ_CP045054:233442-233693 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT141148 NZ_CP059840:c234649-234583 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT