Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 222714..223270 Replicon plasmid pLG24p2
Accession NZ_CP045054
Organism Salmonella enterica subsp. enterica serovar Muenchen strain LG24

Toxin (Protein)


Gene name relE Uniprot ID A0A3R0U7A1
Locus tag SMLG24_RS01390 Protein ID WP_000404186.1
Coordinates 222995..223270 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SMLG24_RS01385 Protein ID WP_065314520.1
Coordinates 222714..222995 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMLG24_RS01380 221891..222631 + 741 WP_057395086.1 conjugal transfer pilus acetylase TraX -
SMLG24_RS01385 222714..222995 + 282 WP_065314520.1 ribbon-helix-helix protein, CopG family Antitoxin
SMLG24_RS01390 222995..223270 + 276 WP_000404186.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMLG24_RS01395 223308..223871 + 564 WP_057395085.1 fertility inhibition protein FinO -
SMLG24_RS01400 224190..224450 + 261 WP_097361646.1 hypothetical protein -
SMLG24_RS01405 225004..225348 + 345 WP_057395081.1 hypothetical protein -
SMLG24_RS01410 225380..225703 + 324 WP_023223027.1 PerC family transcriptional regulator -
SMLG24_RS01415 225697..226068 + 372 Protein_244 hypothetical protein -
SMLG24_RS01420 226257..226463 + 207 WP_023223029.1 hemolysin expression modulator Hha -
SMLG24_RS25920 226593..226810 + 218 Protein_246 DUF465 domain-containing protein -
SMLG24_RS01430 227110..227931 + 822 WP_057395079.1 thioredoxin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..270881 270881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11810.03 Da        Isoelectric Point: 12.7590

>T141147 WP_000404186.1 NZ_CP045054:222995-223270 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKK

Download         Length: 276 bp

>T141147 NZ_CP059840:234214-234321 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>AT141147 WP_065314520.1 NZ_CP045054:222714-222995 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>AT141147 NZ_CP059840:c234166-234100 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R0U7A1

Antitoxin

Source ID Structure

References