Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 168784..169309 Replicon plasmid pLG24p2
Accession NZ_CP045054
Organism Salmonella enterica subsp. enterica serovar Muenchen strain LG24

Toxin (Protein)


Gene name ccdB Uniprot ID A0A5J1SSZ4
Locus tag SMLG24_RS01070 Protein ID WP_001159865.1
Coordinates 169004..169309 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SMLG24_RS01065 Protein ID WP_079953237.1
Coordinates 168784..169002 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMLG24_RS01045 163983..164225 - 243 WP_057394653.1 type II toxin-antitoxin system ParD family antitoxin -
SMLG24_RS01050 164486..165451 + 966 WP_057394652.1 DNA-binding protein -
SMLG24_RS01055 165538..166305 + 768 WP_097361665.1 3'-5' exonuclease -
SMLG24_RS01060 166984..168072 - 1089 WP_097361622.1 transcriptional regulator -
SMLG24_RS01065 168784..169002 + 219 WP_079953237.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
SMLG24_RS01070 169004..169309 + 306 WP_001159865.1 type II toxin-antitoxin system toxin CcdB Toxin
SMLG24_RS01075 169311..169601 + 291 WP_097361623.1 cytoplasmic protein -
SMLG24_RS01080 169598..170134 + 537 Protein_178 cytoplasmic protein -
SMLG24_RS01085 170147..170929 + 783 WP_079953235.1 site-specific integrase -
SMLG24_RS01090 171079..172008 - 930 WP_057394647.1 Rpn family recombination-promoting nuclease/putative transposase -
SMLG24_RS01095 172423..173628 + 1206 WP_000427674.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..270881 270881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T141146 WP_001159865.1 NZ_CP045054:169004-169309 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T141146 NZ_CP059839:c82139-81990 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCTACGGTGTTCTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT141146 WP_079953237.1 NZ_CP045054:168784-169002 [Salmonella enterica subsp. enterica serovar Muenchen]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT141146 NZ_CP059839:82183-82244 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1SSZ4

Antitoxin

Source ID Structure

References